8,8''-二黄芩素 | 135309-02-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 8,8''-二黄芩素
• 英文名称: 8,8''-bibaicalein
• 英文别名: 5,6,7-trihydroxy-2-phenyl-8-(5,6,7-trihydroxy-4-oxo-2-phenylchromen-8-yl)chromen-4-one
• CAS: 135309-02-3
• 化学式: C₃₀H₁₈O₁₀
• 分子量: 538.467
• InChiKey: NRYPLIKKTVVLMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  8,8''-二黄芩素 生成 5,6,7,5',6',7'-Hexamethoxy-2,2'-diphenyl-[8,8']bichromenyl-4,4'-dione
  参考文献：
  名称：

  KIKUCHI, YUICHI;MIYAICHI, YUKINORI;YAMAGUCHI, YUMI;KIZU, HARUHISA;TOMIMOR+, CHEM. AND PHARM. BULL., 39,(1991) N, C. 199-201

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR SYNTHESIS OF OROXYLIN A<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'OROXYLINE A
  申请人：MAJEED MUHAMMED

  公开号：WO2020032913A1

  公开（公告）日：2020-02-13

  Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalm is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A gluciironide methyl ester which on de- glycosylation results in the formation of Oroxylin A.

  揭示了一种新颖、简单、可扩展且环境友好的过程，用于从黄芩苷合成黄芩素A。将黄芩苷酯化以获得甲酯，进一步选择性地甲基化以提供黄芩素A葡糖苷甲酯，脱糖后形成黄芩素A。
• Process for synthesis of Oroxylin A
  申请人：Majeed Muhammed

  公开号：US10407401B1

  公开（公告）日：2019-09-10

  Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.

  揭示了一种新颖、简单、可扩展且环境友好的过程，用于从黄芩苷合成黄芩素A。将黄芩苷酯化以获得甲酯，进一步选择性地进行甲基化以提供甲酯化的黄芩素A葡萄糖苷，脱糖后形成黄芩素A。
• Studies on the constituents of Scutellaria species. XIV. On the constituents of the roots and the leaves of Scutellaria alpina L.
  作者：Yuichi KIKUCHI、Yukinori MIYAICHI、Yumi YAMAGUCHI、Haruhisa KIZU、Tsuyoshi TOMIMORI、Karin VETSCHERA

  DOI：10.1248/cpb.39.199

  日期：——

  From Scutellaria alpina L., two new flavones (I and II) were isolated, together with eighteen known flavonoids. The structures of I and II were shown to be 5, 2', 6'-trihydroxy-6, 7, 8-trimethoxyflavone and 5, 5", 6, 6", 7, 7"-hexahydroxy-8, 8"-biflavone(8, 8"-bibaicalein) on the basis of the chemical and spectral data. Compound I has already been synthesized.

  从高山黄芩（Scutellaria alpina L.）中分离出了两种新的黄酮类化合物（I 和 II）以及 18 种已知的黄酮类化合物。根据化学和光谱数据，I 和 II 的结构分别为 5, 2', 6'-trihydroxy-6, 7, 8-trimethoxyflavone 和 5, 5", 6, 6", 7, 7"-hexahydroxy-8, 8"-biflavone(8, 8"-bibaicalein) 。化合物 I 已经合成。
• KIKUCHI, YUICHI;MIYAICHI, YUKINORI;YAMAGUCHI, YUMI;KIZU, HARUHISA;TOMIMOR+, CHEM. AND PHARM. BULL., 39,(1991) N, C. 199-201
  作者：KIKUCHI, YUICHI、MIYAICHI, YUKINORI、YAMAGUCHI, YUMI、KIZU, HARUHISA、TOMIMOR+

  DOI：——

  日期：——