7-(diethylamino)-3-(4-(3-methoxy-4-(1,4,7,10-tetraoxa-13-azacyclopentadecan-13-yl)phenyl)-1H-1,2,3-triazol-1-yl)-2H-chromen-2-one | 1398940-08-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(diethylamino)-3-(4-(3-methoxy-4-(1,4,7,10-tetraoxa-13-azacyclopentadecan-13-yl)phenyl)-1H-1,2,3-triazol-1-yl)-2H-chromen-2-one
• 英文别名: 3-{4-[3-methoxy-4-(1,4,7,10,-tetraoxa-13-azacyclopentadecan-13-yl)phenyl]-1H-1,2,3-triazol-1-yl}-7-(diethylamino)-2H-chromen-2-one；7-(Diethylamino)-3-[4-[3-methoxy-4-(1,4,7,10-tetraoxa-13-azacyclopentadec-13-yl)phenyl]triazol-1-yl]chromen-2-one
• CAS: 1398940-08-3
• 化学式: C₃₂H₄₁N₅O₇
• 分子量: 607.707
• InChiKey: MOTYBACTIUTLAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  4-formyl-2-methoxyphenylaza-15-crown-5 在 copper(ll) sulfate pentahydrate 、 (1-重氮基-2-氧代丙基)膦酸二甲酯 、 potassium carbonate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 68.0h， 生成 7-(diethylamino)-3-(4-(3-methoxy-4-(1,4,7,10-tetraoxa-13-azacyclopentadecan-13-yl)phenyl)-1H-1,2,3-triazol-1-yl)-2H-chromen-2-one
  参考文献：
  名称：

  Fluorescence lifetime-based sensing of sodium by an optode

  摘要：

  我们报道了一种用于检测Na+的1,2,3-三唑类荧光离子传感器，该传感器在体外显示出Na+诱导的荧光强度和衰减时间的增强。

  DOI：

  10.1039/c4cc06112h

文献信息

• [EN] ? (PI)-CONJUGATED FLUOROIONOPHORES AND METHOD FOR DETERMINING AN ALKALI ION<br/>[FR] FLUOROIONOPHORES p-CONJUGUÉS ET MÉTHODE DE DOSAGE D'UN ION ALCALIN
  申请人：UNIV POTSDAM

  公开号：WO2012120141A1

  公开（公告）日：2012-09-13

  The present invention relates to π-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion. Fluoroionophoric compounds of the general formula I are described Ionophore – π-Linker - Fluorophore (I) wherein the Ionophore is an anilino containing crown ether or cryptand with one or more anilino donor moieties as electron donors, forming a stable complex with an alkali metal ion the π-Linker is an aromatic or heteroaromatic conjugative linking moiety, and the Fluorophore is an electron acceptor moiety. Variation of the ionophoric unit offers a broad spectrum of detectable K+ and Na+ -concentrations, ranging from high concentration around 800 mM down to very low concentrations around 3 mM. The fluoroionophores have great potential for application in fluorescent optode system based blood analyzing equipment for methods and kits for the determination of K+ and Na+ concentrations in biological systems, either in vitro or in vivo, using embodiments of the disclosed fluoroionophores.

  本发明涉及π-共轭氟离子探针，其制备方法以及它们的使用和一种用于确定碱金属离子的方法。描述了一般式I的氟离子探针化合物 离子载体 - π-连接体 - 荧光团（I），其中离子载体是含有一个或多个苯胺供体基团作为电子给体的冠醚或cryptand，与碱金属离子形成稳定络合物，π-连接体是芳香或杂芳共轭连接基团，荧光团是电子受体基团。离子载体单元的变化提供了广泛的可检测K+和Na+浓度范围，从约800 mM的高浓度到约3 mM的非常低浓度。这些氟离子探针在基于荧光光电系统的血液分析设备中具有巨大的应用潜力，用于检测生物系统中K+和Na+浓度的方法和试剂盒，无论是体外还是体内，都可以使用所披露的氟离子探针的实施方式。
• II (PI)-CONJUGATED FLUOROIONOPHORES AND METHOD FOR DETERMINING AN ALKALI ION
  申请人：Universität Potsdam

  公开号：EP2683714A1

  公开（公告）日：2014-01-15
• PI-CONJUGATED FLUOROIONOPHORES AND METHOD FOR DETERMINING AN ALKALI ION
  申请人：Ast Sandra

  公开号：US20130344607A1

  公开（公告）日：2013-12-26

  The present invention relates to π-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion. Fluoroionophoric compounds of the general formula I are described Ionophore-π-Linker-Fluorophore  (I) wherein the Ionophore is an anilino containing crown ether or cryptand with one or more anilino donor moieties as electron donors, forming a stable complex with an alkali metal ion the π-Linker is an aromatic or heteroaromatic conjugative linking moiety, and the Fluorophore is an electron acceptor moiety. Variation of the ionophoric unit offers a broad spectrum of detectable K + and Na + -concentrations, ranging from high concentration around 800 mM down to very low concentrations around 3 mM. The fluoroionophores have great potential for application in fluorescent optode system based blood analyzing equipment for methods and kits for the determination of K + and Na + concentrations in biological systems, either in vitro or in vivo, using embodiments of the disclosed fluoroionophores.