2,2,4,4-Tetramethyl-glutaramidsaeure | 1189-81-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,4,4-Tetramethyl-glutaramidsaeure
• 英文别名: 5-Amino-2,2,4,4-tetramethyl-5-oxopentanoic acid；5-amino-2,2,4,4-tetramethyl-5-oxopentanoic acid
• CAS: 1189-81-7
• 化学式: C₉H₁₇NO₃
• 分子量: 187.239
• InChiKey: GDUPDTIYZCTHJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,4,4-四甲基戊二酸酐 在 ammonium hydroxide 作用下， 以 丙酮 为溶剂， 生成 2,2,4,4-Tetramethyl-glutaramidsaeure
  参考文献：
  名称：

  The Effect of Axial Alkyl Groups on the Base Strengths of Cyclic Amines

  摘要：

  DOI：

  10.1021/jo01034a002

文献信息

• [EN] CONJUGATED PROTEINS WITH PROLONGED IN VIVO EFFICACY<br/>[FR] PROTÉINES CONJUGUÉES À EFFICACITÉ IN VIVO PROLONGÉE
  申请人：NOVO NORDISK AS

  公开号：WO2010015668A1

  公开（公告）日：2010-02-11

  The invention relates to conjugated proteins, in particular but not exclusively, blood coagulation factors, to processes for preparing said conjugates, to pharmaceutical compositions comprising said conjugates and to the use of the conjugates in therapy, in particular but not exclusively, for the treatment of diseases alleviated by blood coagulation factors such as the prophylactic treatment of hemophilia.
• [EN] SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION<br/>[FR] SYNTHÈSE DE 2',3'-DIDÉSOXYNUCLÉOSIDE POUR SYNTHÈSE D'ADN AUTOMATIQUE ET POLYMÉRISATION ACTIVÉE PAR PYROPHOSPHOLYSE
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2011150277A2

  公开（公告）日：2011-12-01

  Methods for preparation of 2',3'-dideoxynucleotides support structures, such as 2',3'-dideoxyguanosine, 2',3'- dideoxyadenosine, and 3'-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
• [EN] BIVALENT COMPOUNDS, CONJUGATES AND USES THEREOF<br/>[FR] COMPOSÉS BIVALENTS, CONJUGUÉS ET LEURS UTILISATIONS
  申请人：[en]RISEN (SUZHOU) PHARMA TECH CO., LTD.

  公开号：WO2022266753A1

  公开（公告）日：2022-12-29

  There are provided conjugates of Formula (V) wherein R1 is a triantennary targeting moiety comprising N-acetyl galactosamine and R2 is a bioactive agent which is preferably an oligonucleotide, as well as pharmaceutical compositions and methods of use of the conjugates for the treatment, inhibition, or prevention of diseases and disorders which are therapeutic targets of the bioactive agent. In preferred embodiments the conjugate preferentially binds to asiaglycoprotein receptors (ASGPR). In preferred embodiments, the oligonucleotide is SiRNA which targets the PCSK9 gene, providing treatment options for lipid disorders such as hyperlipidemia.
• The Effect of Axial Alkyl Groups on the Base Strengths of Cyclic Amines
  作者：H. K. Hall

  DOI：10.1021/jo01034a002

  日期：1964.11