N-(4,5-dimethyl-1,3-thiazol-2-yl)formamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4,5-dimethyl-1,3-thiazol-2-yl)formamide
• 化学式: C₆H₈N₂OS
• mdl: MFCD00727997
• 分子量: 156.21
• InChiKey: BSZHOUVFAYBUQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel succinate compounds, compositions and methods of use and preparation
  申请人：——

  公开号：US20020115863A1

  公开（公告）日：2002-08-22

  Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  揭示了一种新型羟羧酸化合物。这些羟羧酸酯抑制肽变形酶（PDF），这是一种存在于原核生物中的酶。这些羟羧酸酯可用作抗微生物和抗生素。该发明的化合物表现出对肽变形酶的选择性抑制，而不影响其他金属蛋白酶如基质金属蛋白酶（MMPs）。该文还揭示了这些化合物的合成方法和使用方法。
• Novel urea compounds, compositions and methods of use and preparation
  申请人：——

  公开号：US20020119962A1

  公开（公告）日：2002-08-29

  Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

  揭示了一种新型羟羧酸类化合物。这些羟羧酸酯抑制肽变形酶（PDF），这是一种存在于原核生物中的酶，因此可用作抗微生物和抗生素。还公开了这些化合物的合成和使用方法。
• [EN] NOVEL UREA COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION<br/>[FR] NOUVEAUX COMPOSES A BASE D'UREE, COMPOSITIONS LES CONTENANT, ET PROCEDES D'UTILISATION ET DE PREPARATION DE CEUX-CI
  申请人：VERSICOR INC

  公开号：WO2001044178A1

  公开（公告）日：2001-06-21

  Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and use of the compounds are also disclosed.

  本发明揭示了化学式(I)的新型羟肟酸化合物。这些羟肟酸盐可以抑制肽变形酶(PDF)的活性，该酶存在于原核生物中，因此可用作抗微生物和抗生素。本发明还揭示了这些化合物的合成方法和使用方法。
• [EN] NOVEL SUCCINATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND PREPARATION<br/>[FR] NOUVEAUX COMPOSES A BASE DE SUCCINATE, COMPOSITIONS LES CONTENANT, ET PROCEDES D'UTILISATION ET DE PREPARATION DE CEUX-CI
  申请人：VERSICOR INC

  公开号：WO2001044179A1

  公开（公告）日：2001-06-21

  Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

  本发明揭示了式（I）的新型羟肟酸化合物。这些羟肟酸盐抑制肽变形酶（PDF），一种存在于原核生物中的酶。这些羟肟酸盐可用作抗微生物和抗生素。本发明的化合物显示出对肽酰变形酶的选择性抑制，而不是其他金属蛋白酶如基质金属蛋白酶（MMPs）。本发明还揭示了这些化合物的合成和使用方法。
• Compounds
  申请人：Adams Jerry Leroy

  公开号：US20080194561A1

  公开（公告）日：2008-08-14

  A compound of formula (I): compositions and medicaments containing the same as well as processes for the preparation and use of such compounds, compositions and medicaments, particularly in diseases associated with inappropriate Aurora activity.

  公式（I）的化合物：包含该化合物的组合物和药物，以及制备和使用这些化合物、组合物和药物的方法，特别是用于与不适当的极光活动有关的疾病。