ethyl 4-[(1,3-dioxoinden-2-ylidene)methylamino]benzoate | 64758-86-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: ethyl 4-[(1,3-dioxoinden-2-ylidene)methylamino]benzoate
• CAS: 64758-86-7
• 化学式: C₁₉H₁₅NO₄
• 分子量: 321.332
• InChiKey: BRNPCRZPSLBSKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72.47
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-formylindane-1,3-dione 、 苯佐卡因 以 乙醇 为溶剂， 以66%的产率得到ethyl 4-[(1,3-dioxoinden-2-ylidene)methylamino]benzoate
  参考文献：
  名称：

  New reactions of benzocaine

  摘要：

  Reaction of benzocaine with indane-1,3-dione-2-carbaldehyde afforded the corresponding azomethine. Ethoxymethylenemalonate reacted with benzocaine to form ethyl 4-{[2-(ethoxycarbonyl)-4-methoxy-3-oxobuten-1-yl]amino}benzoate, which was converted to the corresponding quinolone when heated to 185-190A degrees C. Reactions of benzocaine with aliphatic aldehydes furnished 2,3-alkyl-substituted quinolines.

  DOI：

  10.1134/s1070363216110074

文献信息

• New reactions of benzocaine
  作者：Yu. A. Azev、O. S. Ermakova、V. S. Berseneva、V. A. Bakulev

  DOI：10.1134/s1070363216110074

  日期：2016.11

  Reaction of benzocaine with indane-1,3-dione-2-carbaldehyde afforded the corresponding azomethine. Ethoxymethylenemalonate reacted with benzocaine to form ethyl 4-[2-(ethoxycarbonyl)-4-methoxy-3-oxobuten-1-yl]amino}benzoate, which was converted to the corresponding quinolone when heated to 185-190A degrees C. Reactions of benzocaine with aliphatic aldehydes furnished 2,3-alkyl-substituted quinolines.