8-十八碳烯酸甲酯 | 2345-29-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 8-十八碳烯酸甲酯
• 英文名称: 8-octadecenoic acid methyl ester
• 英文别名: Methyl octadec-8-enoate
• CAS: 2345-29-1
• 化学式: C₁₉H₃₆O₂
• 分子量: 296.494
• InChiKey: KXOOHHMDCDXCBV-UHFFFAOYSA-N

物化性质

• 沸点：
  370.9±21.0 °C(Predicted)
• 密度：
  0.873±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 8-octadecenoic acid 在 咪唑 、 碘 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以100%的产率得到8-十八碳烯酸甲酯
  参考文献：
  名称：

  Mild Method for the Selective Esterification of Carboxylic Acids Based on the Garegg−Samuelsson Reaction

  摘要：

  A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I-2, and imidazole allows the selective esterification: of a wide variety of acids with excellent results. The generation of a bulky phosphonitun-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.

  DOI：

  10.1021/jo102395c

文献信息

• Mild Method for the Selective Esterification of Carboxylic Acids Based on the Garegg−Samuelsson Reaction
  作者：Sara P. Morcillo、Luis Álvarez de Cienfuegos、Antonio J. Mota、José Justicia、Rafael Robles

  DOI：10.1021/jo102395c

  日期：2011.4.1

  A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I-2, and imidazole allows the selective esterification: of a wide variety of acids with excellent results. The generation of a bulky phosphonitun-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.