(E)-1-(4,7-dimethoxy-1-benzofuran-5-yl)-3-(3-methoxyphenyl)prop-2-en-1-one | 1025008-60-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-(4,7-dimethoxy-1-benzofuran-5-yl)-3-(3-methoxyphenyl)prop-2-en-1-one
• CAS: 1025008-60-9
• 化学式: C₂₀H₁₈O₅
• 分子量: 338.36
• InChiKey: JOVVJVRPVLASBR-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  57.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(4,7-dimethoxybenzofuran-5-yl)ethan-1-one 、 3-甲氧基苯甲醛 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以36%的产率得到(E)-1-(4,7-dimethoxy-1-benzofuran-5-yl)-3-(3-methoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

  摘要：

  Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.099

文献信息

• Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3
  作者：Julia Cianci、Jonathan B. Baell、Bernard L. Flynn、Robert, W. Gable、Jorgen A. Mould、Dharam Paul、Andrew J. Harvey

  DOI：10.1016/j.bmcl.2008.01.099

  日期：2008.3

  Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones. (c) 2008 Elsevier Ltd. All rights reserved.