γ-glutamyl-S-propyl-L-cysteine | 91212-00-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-glutamyl-S-propyl-L-cysteine
• 英文别名: N-γ-glutamyl-S-propylcysteine；gamma-glutamyl-S-propyl cysteine；(2S)-2-amino-5-[[(1R)-1-carboxy-2-propylsulfanylethyl]amino]-5-oxopentanoic acid
• CAS: 91212-00-9
• 化学式: C₁₁H₂₀N₂O₅S
• 分子量: 292.356
• InChiKey: MTFUIXBAXHURMH-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-ethyl 5-dicyclohexylammonio-N-trifluoroacetyl-(2S)-glutamate 在 sodium hydroxide 、 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 γ-glutamyl-S-propyl-L-cysteine
  参考文献：
  名称：

  Carson,J.F.; Wong,F.F., Journal of the Chemical Society. Perkin transactions I, 1974, p. 685 - 687

  摘要：

  DOI：

文献信息

• Compositions for use in golf balls
  申请人：Bulpett A. David

  公开号：US20050245652A1

  公开（公告）日：2005-11-03

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  高尔夫球由内核、外覆盖层和可选的中间层组成，外覆盖层可以包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强物理特性和/或性能特征（例如反弹系数）的组合物。最好，内核的反弹系数为0.8或更高。
• COMPOSITIONS FOR USE IN GOLF BALLS
  申请人：Sullivan Michael J.

  公开号：US20080227567A1

  公开（公告）日：2008-09-18

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  一个高尔夫球包括一个核心、一个外覆盖层，以及可选的介质层，介质层位于核心和外覆盖层之间。外覆盖层可能包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强高尔夫球物理性能和/或性能特征（例如反弹系数）的组成。最好，核心的反弹系数为0.8或更高。
• Compositions for Use in Golf Balls
  申请人：Bulpett David A.

  公开号：US20080176678A1

  公开（公告）日：2008-07-24

  A golf ball comprising a core and at least one layer disposed about the core, wherein at least one of the core or the layer is formed from a composition comprising a base polymer, a crosslink initiator, and an additive comprising an aromatic iodonium compound or an aromatic iodonium salt.

  一颗高尔夫球包括一个核心和至少一层沿核心排列的材料，其中核心或层中的至少一个是由包含基础聚合物、交联引发剂和添加剂的组合物形成的，该添加剂包括芳香碘化物或芳香碘化盐。
• REMEDIES FOR BRAIN DISEASES
  申请人：WAKUNAGA PHARMACEUTICAL CO., LTD.

  公开号：EP0885608A1

  公开（公告）日：1998-12-23

  The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1):         CH2=CH-CH2-S(O)n-R     (1) [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl group, a substituted alkenyl group, an alkylthio group, an alkenylthio group, a phenyl group, a substituted phenyl group, a heterocyclic group, or a group derived from an amino acid or an oligopeptide by deletion of one hydrogen atom, and which group may have a protective group; and n is 0, 1, or 2], a glycoside thereof, or a salt of the compound or the glycoside. The drug of the present invention for ameliorating brain diseases, inhibiting reduction of brain neurons and promoting branching of neurites, is useful for the prevention and treatment of brain diseases such as dementia in association with degeneration and sloughing of brain neurons.

  本发明公开了式 (1) 所代表的化合物在制造脑疾病预防和治疗药物中的用途： CH2=CH-CH2-S(O)n-R (1) [其中 R 代表氢原子、烷基、烯基、取代的烷基、取代的烯基、烷硫基、烯硫基、苯基、取代的苯基、杂环基、或由氨基酸或低聚肽去掉一个氢原子衍生的基团，该基团可带有保护基；且 n 为 0、1 或 2]、其糖苷或该化合物或该糖苷的盐。 本发明用于改善脑部疾病、抑制脑神经元减少和促进神经元分支的药物可用于预防和治疗与脑神经元变性和脱落有关的痴呆等脑部疾病。
• NATURAL FLAVOUR ENHANCERS AND THE METHOD FOR MAKING SAME
  申请人：Pepsico

  公开号：EP2496097B1

  公开（公告）日：2016-03-30