7-Methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-on | 5571-63-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-Methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-on
• 英文别名: 7-Methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepinon-(2)；7-Methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-on；7-Methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
• CAS: 5571-63-1
• 化学式: C₁₆H₁₄N₂O
• 分子量: 250.3
• InChiKey: ZZLQGKUTUGIQNL-UHFFFAOYSA-N

物化性质

• 溶解度：
  >37.5 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-Methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-on 、 sodium methylate 、 2-氯乙醇 以36%的产率得到
  参考文献：
  名称：

  BOGATSKIJ A. V.; ZHILINA Z. I.; ANDRONATI S. A.; ISAEV S. D.; YURCHENKO A+, FIZIOL. AKTIV. VESHCHESTVA, KIEV, 1979, HO 11, 55-59

  摘要：

  DOI：

文献信息

• ANXIOLYTIC AGENTS WITH REDUCED SEDATIVE AND ATAXIC EFFECTS
  申请人：COOK M. James

  公开号：US20070049580A1

  公开（公告）日：2007-03-01

  Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

  本文披露了口服活性苯二氮平衍生物及其盐。这些化合物及其盐具有抗焦虑和抗惊厥活性，并减少了镇静/催眠/肌肉松弛/共济失调的副作用。
• TEST KIT FOR THE QUANTITATIVE DETERMINATION OF NARCOTIC DRUGS
  申请人：CHIRON AS

  公开号：US20150204893A1

  公开（公告）日：2015-07-23

  A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, wherein the isotopologue differs from vessel to vessel and—wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of 13 C, 15 N and 18 O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs.

  一种用于定量测定麻醉药物的检测试剂盒，包括（A）一系列密封容器，每个容器中含有一种去氘同位素麻醉药物，其浓度和数量均被精确定义，其中同位素从容器到容器不同，同位素的数量在容器到容器之间不同或对所有容器都相同；和/或（B）一系列密封容器，每个容器中含有相同的同位素，其浓度和数量被精确定义，数量在容器到容器之间不同；其中自由同位素选自麻醉药物、前药、盐、溶剂、水合物和多晶形，并且在分子中至少包含三种稳定同位素，所述稳定同位素选自13C、15N和18O，其标记度至少为95摩尔％；使用该检测试剂盒和一种定量测定麻醉药物的方法。
• POSITIVE ALLOSTERIC MODULATORS OF THE GABA-A RECEPTOR IN THE TREATMENT OF AUTISM
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US20150313913A1

  公开（公告）日：2015-11-05

  Provided herein are methods and formulations for treating an Autism Spectrum Disorder using low doses of an agent that enhances signaling through the GABA receptor.
• US3966793A
  申请人：——

  公开号：US3966793A

  公开（公告）日：1976-06-29
• US8835424B2
  申请人：——

  公开号：US8835424B2

  公开（公告）日：2014-09-16