Biphenyl-2-ylcarbamic Acid | 50443-60-2

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Biphenyl-2-ylcarbamic Acid
• 英文别名: (2-phenylphenyl)carbamic acid
• CAS: 50443-60-2
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.23
• InChiKey: QMOVGVNKXUTCQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-((1R)-2-amino-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-8-hydroxyquinolin-2(1H)-one acetate 、 三乙酰氧基硼氢化钠 、 二氯甲烷 在 水 作用下， 以 甲醇 为溶剂， 反应 16.5h， 生成 Biphenyl-2-ylcarbamic Acid
  参考文献：
  名称：

  Biphenyl derivatives

  摘要：

  本发明提供了式I的双苯基衍生物：其中R1、R2、R3、R4、R5、R6、R7、W、a、b和c如规范中所定义，或其药学上可接受的盐、溶剂或立体异构体。本发明的双苯基衍生物具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这种双苯基衍生物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

  公开号：

  US20060223858A1

文献信息

• Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
  申请人：Mammen Mathai

  公开号：US20050113417A1

  公开（公告）日：2005-05-26

  The invention is directed to compounds of formula I: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7a , R 7b , W, G 1 , G 2 , a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  这项发明涉及到以下式I的化合物：其中R1、R2、R3、R4、R5、R6、R7a、R7b、W、G1、G2、a、b、c、d和m如规范中所定义，或其药学上可接受的盐、溶剂或立体异构体。该发明还涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• [EN] "INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, COMPOSITIONS, PRODUCTS AND USES THEREOF"<br/>[FR] "INHIBITEURS DE NICOTINAMIDE PHOSPHORIBOSYLTRANSFÉRASE, COMPOSITIONS, PRODUITS ET LEURS UTILISATIONS"
  申请人：UNIVERSIT DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO

  公开号：WO2014178001A1

  公开（公告）日：2014-11-06

  Compounds of formula (I): able to inhibit nicotinamide phosphoribosyltransferase. The disclosure also relates to the use of compounds of formula (I) for treatment of pathological conditions in which NAMPT inhibition might be beneficial, such as acute and chronic inflammation, cancer and metabolic disorders.

  化学式（I）的化合物：能够抑制烟酰胺磷酸核糖转移酶。该公开还涉及使用化学式（I）的化合物来治疗可能受益于NAMPT抑制的病理条件，如急性和慢性炎症、癌症和代谢紊乱。
• Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
  申请人：Colson Pierre-Jean

  公开号：US20070249675A1

  公开（公告）日：2007-10-25

  This invention relates to compounds of formula I: wherein R 1 and R 2 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions and combinations comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compound to, for example, treat pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

  本发明涉及式I的化合物：其中R1和R2如规范中定义，或其药用可接受的盐或溶剂或立体异构体。该发明还涉及包含这类化合物的药物组合物和配方，用于制备这类化合物的过程和中间体，以及使用这类化合物治疗肺部疾病，如慢性阻塞性肺病和哮喘等方法。
• Biphenyl compounds useful as muscarinic receptor antagonists
  申请人：Ji Yu-Hua

  公开号：US20060205775A1

  公开（公告）日：2006-09-14

  The invention provides compounds of formula I: wherein a, b, c, d, n, R 1 , R 2 , R 3 , R 6 , R 7 , W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

  该发明提供了化合物I的结构式：其中a、b、c、d、n、R1、R2、R3、R6、R7、W和A如规范中定义。化合物I是肌气管受体拮抗剂。该发明还提供含有这种化合物的药物组合物，用于制备这种化合物的过程和中间体，以及使用这种化合物治疗肺部疾病的方法。
• [EN] HYDROCHLORIDE SALT OF BIPHENYL-2-YL-CARBAMIC ACID 1-{9-[(3-FLUORO-4-HYDROXY-BENZOYL)-METHYL-AMINO]-NONYL}-PIPERIDIN-4-YL ESTER<br/>[FR] SEL DE CHLORHYDRATE DU BIPHÉNYL-2-YL-CARBAMATE DE 1-{9-[(3-FLUORO-4-HYDROXY-BENZOYL)-MÉTHYL-AMINO]-NONYL}-PIPÉRIDIN-4-YLE
  申请人：PFIZER LTD

  公开号：WO2011083387A1

  公开（公告）日：2011-07-14

  This invention relates to the hydrochloride salt of biphenyl-2-yl-carbamic acid -9-[(3-fluoro-4-hydroxy-benzoyl)-methyl-amino]-nonyl}-piperidin-4-yl ester and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, said compound. The invention also relates to the hydrates, solvates and polymorphs of the hydrochloride salt of Biphenyl-2-yl-carbamic acid 1-9-[(3-fluoro-4-hydroxy-benzoyl)-methyl- amino]-nonyl}-piperidin-4-yl ester.

  本发明涉及联苯基-2-基-氨基甲酸盐酸盐-9-[(3-氟-4-羟基苯甲酰)-甲基-氨基]-壬基}-哌啶-4-基酯的制备方法，用于制备中间体，含有该化合物的组合物以及该化合物的用途。本发明还涉及联苯基-2-基-氨基甲酸1-9-[(3-氟-4-羟基苯甲酰)-甲基-氨基]-壬基}-哌啶-4-基酯的盐酸盐的水合物、溶剂化合物和多晶形态。