2-cyclooctyloxirane | 90146-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 2-cyclooctyloxirane
• CAS: 90146-76-2
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: UTSRGBWFONXHAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-cyclooctyloxirane 在 盐酸 、 lithium aluminium tetrahydride 、 正丁基锂 、 叠氮化锂 、 三氟化硼乙醚 作用下， 以 乙醚 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.0h， 生成 (1R,3S)-1-Aminomethyl-3-cyclooctyl-isochroman-5,6-diol; hydrochloride
  参考文献：
  名称：

  Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor

  摘要：

  The synthesis and dopaminergic activity of a series of C3 and nitrogen-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans (isochromans) is described. The synthesis of the compounds was stereospecific for the 1,3 cis isomer, and the enantioselective synthesis of both enantiomers of one of the analogoues (20) was achieved. It was determined that all of the dopaminergic activity resides in the [1R,3S] isomer. Generally, substitution at the C3 position provided compounds with very high potency (< 10 nm EC50) and selectivity for the D1 receptor, with a wide range of intrinsic activities (60-160%). Analogues containing C3 substituents including aryl, arylalkyl, and cyclic and acyclic alkyl groups showed a marked enhancement of dopaminergic activity compared to the unsubstituted compound. As a class, the drugs were orally active in the rat rotation model with a very long duration of action.

  DOI：

  10.1021/jm00112a034

文献信息

• High glass transition temperature polycarbonates derived from adamantane epoxides
  申请人：PROMERUS, LLC

  公开号：US10626216B2

  公开（公告）日：2020-04-21

  Embodiments in accordance with the present invention relate generally to polycarbonate polymers having repeat units derived from adamantane epoxide monomers and methods of using such polymers and compositions containing them. The compositions thus formed are useful in a variety of optoelectronic device fabrications.

  根据本发明的实施方案，一般涉及具有源自金刚烷环氧单体的重复单元的聚碳酸酯聚合物，以及使用这种聚合物和含有它们的组合物的方法。由此形成的组合物可用于各种光电设备制造。
• HIGH GLASS TRANSITION TEMPERATURE PHOTOIMAGEABLE POLYCARBONATE POLYMERS WITH PENDENT POLYCYCLIC FUNCTIONAL GROUPS
  申请人：PROMERUS, LLC

  公开号：US20150353679A1

  公开（公告）日：2015-12-10

  Embodiments in accordance with the present invention relate generally to polycarbonate polymers having repeat units derived from polycyclic-epoxide monomers and methods of using such polymers and compositions containing them, and more specifically to polymers and compositions of polycarbonates that encompass repeat units derived from norbornane and tetracyclododecane, and methods of using such compositions.
• HIGH GLASS TRANSITION TEMPERATURE POLYCARBONATES DERIVED FROM ADAMANTANE EPOXIDES
  申请人：Promerus, LLC

  公开号：US20190127522A1

  公开（公告）日：2019-05-02

  Embodiments in accordance with the present invention relate generally to polycarbonate polymers having repeat units derived from adamantane epoxide monomers and methods of using such polymers and compositions containing them. The compositions thus formed are useful in a variety of optoelectronic device fabrications.
• US9527957B2
  申请人：——

  公开号：US9527957B2

  公开（公告）日：2016-12-27
• [EN] HIGH GLASS TRANSITION TEMPERATURE PHOTOIMAGEABLE POLYCARBONATE POLYMERS WITH PENDENT POLYCYCLIC FUNCTIONAL GROUPS<br/>[FR] POLYMÈRES DE POLYCARBONATES PHOTOIMAGEABLES AYANT UNE TEMPÉRATURE DE TRANSITION VITREUSE ÉLEVÉE PORTANT DES GROUPES FONCTIONNELS POLYCYCLIQUES LATÉRAUX
  申请人：PROMERUS LLC

  公开号：WO2014134373A1

  公开（公告）日：2014-09-04

  Embodiments in accordance with the present invention relate generally to polycarbonate polymers having repeat units derived from polycyclic-epoxide monomers of formula (I) and methods of using such polymers and compositions containing them, and more specifically to polymers and compositions of polycarbonates that encompass repeat units derived from norbomane and tetracyclododecane, and methods of using such compositions.