2,2-dichloro-N-[4-[3-ethoxy-5-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]phenyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,2-dichloro-N-[4-[3-ethoxy-5-[3-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]phenyl]acetamide
• 化学式: C₁₉H₁₅Cl₂F₃N₄O₂
• 分子量: 459.2
• InChiKey: JMSJDLSQRFWKLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  69
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors
  申请人：Famulok Michael

  公开号：US20090105286A1

  公开（公告）日：2009-04-23

  The invention relates to drugs and the use thereof, wherein said drugs contain compounds selected from a group comprising general formulas (1), (2), (3) and (4) and/or enantiomers, diastereomers or the pharmaceutically acceptable salts thereof. Said drugs are used for treating autoimmune and tumoral diseases and/or for immunosuppresion.
• USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY
  申请人：Famulok Michael

  公开号：US20100048594A1

  公开（公告）日：2010-02-25

  The invention relates to compounds selected from among the group comprising general formulas (1), (2), (3), and/or (4) and/or the enantiomers, diastereomers, and derivatives thereof, and the pharmaceutically acceptable salts thereof for producing a medicament used for therapeutically and/or preventively treating disease and pathological conditions linked to regulation of the insulin and/or insulin-like growth factor (IGF) signalling pathway and/or for chemically inducing longevity.
• US8163788B2
  申请人：——

  公开号：US8163788B2

  公开（公告）日：2012-04-24