Mycro3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Mycro3
• 英文别名: ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate
• 化学式: C₂₄H₁₇ClF₂N₆O₄
• mdl: MFCD03409284
• 分子量: 526.9
• InChiKey: YPPNLSKYXDXQGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• COMBINATION METHODS FOR TREATMENT OF DISEASE
  申请人：Rahl Peter B.

  公开号：US20130053415A1

  公开（公告）日：2013-02-28

  In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.
• SUPER-ENHANCERS AND METHODS OF USE THEREOF
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20140296218A1

  公开（公告）日：2014-10-02

  The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).
• US9155724B2
  申请人：——

  公开号：US9155724B2

  公开（公告）日：2015-10-13
• [EN] COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES<br/>[FR] COMPOSÉS UTILISABLES EN VUE DU TRAITEMENT OU DE LA PRÉVENTION D'AFFECTIONS CANCÉREUSES
  申请人：BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS

  公开号：WO2015104292A2

  公开（公告）日：2015-07-16

  The present disclosure relates to organic small molecule compounds according to formula (I) for use in treating or preventing cancerous diseases in a mammal, to pharmaceutical compositions comprising such a compound, or to pharmaceutical formulations comprising such a compound or such a composition. The present disclosure also relates to methods of treating or preventing cancerous diseases in a mammal, as well as to a method to screen for a potential therapeutic agent effective in the treatment or prevention of neoplasms, and to an assay system that can be used to screen for a potential therapeutic agent effective in the treatment or prevention of said neoplasms.