8-羟基-辛-5-炔酸 | 1042224-96-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 8-羟基-辛-5-炔酸
• 英文名称: 8-hydroxy-oct-5-ynoic acid
• 英文别名: 8-Hydroxyoct-5-ynoic acid；8-hydroxyoct-5-ynoic acid
• CAS: 1042224-96-3
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: JRYOJVSOZBRNAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-羟基-辛-5-炔酸 在 Pd-BaSO₄ 喹啉 、 氢气 、 溴 、 三苯基膦 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.58h， 生成 methyl 8-bromo-5(Z)-octenoate
  参考文献：
  名称：

  Total synthesis of (.+-.)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid (12-HETE)

  摘要：

  DOI：

  10.1021/jo00222a054
• 作为产物：
  描述：

  7-Hydroxy-4-heptynenitrile 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以70%的产率得到8-羟基-辛-5-炔酸
  参考文献：
  名称：

  Total synthesis of (.+-.)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid (12-HETE)

  摘要：

  DOI：

  10.1021/jo00222a054

文献信息

• Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels
  作者：Shivaputra Patil、Anna N. Bukiya、Wei Li、Alejandro M. Dopico、Duane Miller

  DOI：10.1016/j.bmcl.2008.03.080

  日期：2008.6

  Physiological and pharmacological agents that activate large conductance, voltage-, and calcium- gated potassium (BK) channels located in the smooth muscle are effective vasodilators. Thus, activators of smooth muscle BK channels may be potential therapeutic tools to treat cardiovascular disease associated with vasoconstriction and/or impaired dilation, such as cerebrovascular spasm and constriction. We previously showed that lithocholic acid (LC) and other cholane derivatives activated smooth muscle BK channels and, thus, caused endothelium-independent cerebral artery dilation. However, clinical use of these cholane derivatives could be limited by the actions of these steroids, such as elevation of intracellular calcium and induction of apoptosis. Using LC as template, we designed and synthesized a series of hydroxy-alkynoic acids and corresponding methyl esters, as putative, nonsteroid BK channel activators. Indeed, the newly synthesized compounds effectively and reversibly activated rat cerebrovascular myocyte BK channel at concentrations similar to those found effective with LC. Among all the novel compounds tested, C-10 hydroxy-alkynoic acid methyl ester appears to be the most effective activator of vascular myocyte BK channels. (c) 2008 Elsevier Ltd. All rights reserved.
• Total synthesis of (.+-.)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid (12-HETE)
  作者：Bruce P. Gunn、Dee W. Brooks

  DOI：10.1021/jo00222a054

  日期：1985.11