2,8-Dimethyl-non-8-en-4-ol | 154913-72-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,8-Dimethyl-non-8-en-4-ol
• 英文别名: 2,8-Dimethylnon-8-en-4-ol；2,8-dimethylnon-8-en-4-ol
• CAS: 154913-72-1
• 化学式: C₁₁H₂₂O
• 分子量: 170.295
• InChiKey: NAXBKNMEFQNMIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯乙烯 、 2,8-Dimethyl-non-8-en-4-ol 在 palladium diacetate 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以90%的产率得到6-Isobutyl-2-methyl-2-((E)-3-phenyl-allyl)-tetrahydro-pyran
  参考文献：
  名称：

  Catalytic tandem oxy-palladation and vinylation

  摘要：

  Intramolecular oxy-palladation of hydroxy-alkenes leads to organo-Pd(II) intermediates which can be trapped by alkenes in chain extension by vinyl substitution; catalysis is efficient using a reoxidation system but the process is limited to substrates which cannot undergo beta-hydride elimination from the organo-Pd(II) intermediate.

  DOI：

  10.1016/s0040-4039(00)79288-4
• 作为产物：
  描述：

  5-甲基-5-己烯-1-醛 、 ISOBUTYLMAGNESIUM BROMIDE 生成 2,8-Dimethyl-non-8-en-4-ol
  参考文献：
  名称：

  Catalytic tandem oxy-palladation and vinylation

  摘要：

  Intramolecular oxy-palladation of hydroxy-alkenes leads to organo-Pd(II) intermediates which can be trapped by alkenes in chain extension by vinyl substitution; catalysis is efficient using a reoxidation system but the process is limited to substrates which cannot undergo beta-hydride elimination from the organo-Pd(II) intermediate.

  DOI：

  10.1016/s0040-4039(00)79288-4

文献信息

• Catalytic tandem oxy-palladation and vinylation
  作者：M.F. Semmelhack、W.R. Epa

  DOI：10.1016/s0040-4039(00)79288-4

  日期：1993.11

  Intramolecular oxy-palladation of hydroxy-alkenes leads to organo-Pd(II) intermediates which can be trapped by alkenes in chain extension by vinyl substitution; catalysis is efficient using a reoxidation system but the process is limited to substrates which cannot undergo beta-hydride elimination from the organo-Pd(II) intermediate.