(R)-2-chloro-2-phenyl-propionic acid ethyl ester | 39876-61-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-chloro-2-phenyl-propionic acid ethyl ester
• 英文别名: (R)-2-Chlor-2-phenyl-propionsaeure-aethylester；ethyl (2R)-2-chloro-2-phenylpropanoate
• CAS: 39876-61-4
• 化学式: C₁₁H₁₃ClO₂
• 分子量: 212.676
• InChiKey: WZTSOHDYNQYUAR-LLVKDONJSA-N

物化性质

• 沸点：
  104-108 °C(Press: 21 Torr)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethyl (R)-atrolactate 在 氯化亚砜 作用下， 生成 (R)-2-chloro-2-phenyl-propionic acid ethyl ester
  参考文献：
  名称：

  Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and99mTc-tetrofosmin myocardial single photon emission computed tomography

  摘要：

  We studied the causative mechanism of ampulla (Takotsubo) cardiomyopathy. Methods: We examined 7 patients with ampulla cardiomyopathy by means of coronary angiography, two-dimensional echocardiography and Tc-99m-tetrofosmin myocardial SPECT at the time of emergency admission (acute phase), at 3 to 5 days after the attack (subacute phase) and at 1 month after the attack (chronic phase). The left ventricle was divided into 9 regions on two-dimensional echocardiograms and Tc-99m-tetrofosmin myocardial SPECT images, then the degree of abnormalities in each region was scored in four grades from normal (0) to severely abnormal (3). We injected nicorandil into the coronary arteries and determined the elevation in the ST segment before and after administration. Results: Coronary angiography did not show stenotic lesions in any patient. The acute, subacute and chronic phase myocardial perfusion scores on Tc-99m-tetrofosmin myocardial SPECT were 11.2 +/- 3.4, 2.7 +/- 2.3 and 0.4 +/- 0.5, respectively, and wall motion scores on echocardiograms were 13.0 +/- 3.6, 4.4 +/- 2.2 and 0.6 +/- 0.6, respectively, indicating improvement in all scores during the subacute phase (p < 0.01). The elevation in the ST segment (mm) on the electrocardiogram was improved from 8.3 +/- 2.7 to 4.9 +/- 1.9 after the administration of nicorandil (p < 0.05). Conclusion: These findings indicated that coronary microvascular spasm is one causative mechanism of ampulla cardiomyopathy.

  DOI：

  10.1007/bf02988242

文献信息

• Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and99mTc-tetrofosmin myocardial single photon emission computed tomography
  作者：Kazuki Ito、Hiroki Sugihara、Tatsuya Kawasaki、Tatsuya Yuba、Tomoki Doue、Takuji Tanabe、Yoshihiko Adachi、Shuji Katoh、Akihiro Azuma、Masao Nakagawa

  DOI：10.1007/bf02988242

  日期：2001.8

  We studied the causative mechanism of ampulla (Takotsubo) cardiomyopathy. Methods: We examined 7 patients with ampulla cardiomyopathy by means of coronary angiography, two-dimensional echocardiography and Tc-99m-tetrofosmin myocardial SPECT at the time of emergency admission (acute phase), at 3 to 5 days after the attack (subacute phase) and at 1 month after the attack (chronic phase). The left ventricle was divided into 9 regions on two-dimensional echocardiograms and Tc-99m-tetrofosmin myocardial SPECT images, then the degree of abnormalities in each region was scored in four grades from normal (0) to severely abnormal (3). We injected nicorandil into the coronary arteries and determined the elevation in the ST segment before and after administration. Results: Coronary angiography did not show stenotic lesions in any patient. The acute, subacute and chronic phase myocardial perfusion scores on Tc-99m-tetrofosmin myocardial SPECT were 11.2 +/- 3.4, 2.7 +/- 2.3 and 0.4 +/- 0.5, respectively, and wall motion scores on echocardiograms were 13.0 +/- 3.6, 4.4 +/- 2.2 and 0.6 +/- 0.6, respectively, indicating improvement in all scores during the subacute phase (p < 0.01). The elevation in the ST segment (mm) on the electrocardiogram was improved from 8.3 +/- 2.7 to 4.9 +/- 1.9 after the administration of nicorandil (p < 0.05). Conclusion: These findings indicated that coronary microvascular spasm is one causative mechanism of ampulla cardiomyopathy.