2-acetamido-N-piperidin-4-ylacetamide | 1019775-47-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-acetamido-N-piperidin-4-ylacetamide
• CAS: 1019775-47-3
• 化学式: C₉H₁₇N₃O₂
• 分子量: 199.253
• InChiKey: KXQANYUYDVIOCO-UHFFFAOYSA-N

物化性质

• 沸点：
  500.5±50.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde 、 2-acetamido-N-piperidin-4-ylacetamide 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 N-2-acetyl-N-1-(1-{4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzyl}piperidin-4-yl)glycinamide
  参考文献：
  名称：

  Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

  摘要：

  This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2. This series also shows a high level of selectivity over other closely related kinases and significantly improved caspase-3 activity with the more optimized compounds. (c) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.01.054

文献信息

• Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
  作者：Zhicai Wu、John C. Hartnett、Lou Anne Neilson、Ronald G. Robinson、Sheng Fu、Stanley F. Barnett、Deborah Defeo-Jones、Raymond E. Jones、Astrid M. Kral、Hans E. Huber、George D. Hartman、Mark T. Bilodeau

  DOI：10.1016/j.bmcl.2008.01.054

  日期：2008.2

  This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2. This series also shows a high level of selectivity over other closely related kinases and significantly improved caspase-3 activity with the more optimized compounds. (c) 2008 Published by Elsevier Ltd.