Gly-His-Gly | 7758-33-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-His-Gly
• 英文别名: 2-[[2-[(2-azaniumylacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]acetate
• CAS: 7758-33-0
• 化学式: C₁₀H₁₅N₅O₄
• 分子量: 269.26
• InChiKey: ADZGCWWDPFDHCY-UHFFFAOYSA-N

物化性质

• 熔点：
  224℃
• 沸点：
  856.7±65.0 °C(Predicted)
• 密度：
  1.440

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  potassium tetrachloropalladate(II) 、 Gly-His-Gly 以 重水 为溶剂， 生成 [Pd(Gly-His-Gly-N,N',N3)Cl]
  参考文献：
  名称：

  含甲硫氨酸和组氨酸的四肽与不同的Pd（II）和Pt（II）配合物的反应的研究：通过肽的电镀和催化剂的空间修饰选择性地裂解酰胺键。

  摘要：

  （1）H NMR光谱用于研究[M（en）（H（2）O）（2）]（2+）配合物（M = Pd（ii）和Pt（ii））与N-乙酰化的甲硫酰基-甘氨酰-组氨酸-甘氨酰胺，MeCOMet-Gly-His-GlyNH（2）。所有反应均在60℃下于1.5-2.0 pH范围内用等摩尔量的[M（en）（H（2）O）（2）]（2+）配合物和四肽进行。与甲硫氨酸残基结合的金属（ii）配合物影响涉及甲硫氨酸羧基的酰胺键的区域选择性裂解。与该肽中的其他酰胺键相比，Met-Gly酰胺键的切割优先级归因于Pt（ii）和Pd（ii）离子对硫供体原子的高度亲和力。讨论了这些水解反应的机理，并为澄清起见，[Pd（en）（H（2）O）（2）]（2+）配合物与MeCOMet-Gly-His-GlyNH（2）的反应还通过电位滴定法进行了研究。[Pd（L）（H（2）O）（2）]（2+）类型的各种钯（ii）配合物的空间效应，其中L是

  DOI：

  10.1039/b908182h

文献信息

• C-TERMINUS AMIDATION ENZYME COMPOSITION, PROCESS FOR ITS PREPARATION AND ITS USE
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0447547A1

  公开（公告）日：1991-09-25

  A C-terminus amidation enzyme composition of serum or blood plasma origin, which acts on a C-terminus glycine adduct represented by formula (I) (wherein A represents a residue other than α-amino or imino group and α-carboxyl group of a natural α-amino acid origin, and X represents a hydrogen atom or a residue of an amino acid derivative bound to the N atom via a carbonyl group) to produce a C-terminus amidation product represented by formula (II) (wherein A and X are as defined above) and glyoxylic acid, is disclosed. A process for preparing the composition and its use are also disclosed.

  一种来源于血清或血浆的 C-端酰胺化酶组合物，它作用于式(I)代表的 C-端甘氨酸加合物（其中 A 代表除天然 α-氨基酸来源的 α-氨基或亚胺基和 α-羧基以外的残基），X 代表氢原子或通过羰基与 N 原子结合的氨基酸衍生物残基、和 X 代表氢原子或通过羰基与 N 原子结合的氨基酸衍生物残基），以产生由式 (II) 代表的 C 端酰胺化产物（其中 A 和 X 如上定义）和乙醛酸。还公开了制备该组合物的工艺及其用途。
• Enzyme participating in c-terminal amidation, and method of preparing same and use thereof
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0666318A1

  公开（公告）日：1995-08-09

  An enzyme catalyzing the conversion of a peptide C-terminal glycine adduct represented by the following formula (I): (wherein A represents a residue other than α-amino group or imino group and α-carboxylic group derived from naturally occurring α-amino acid, X represents hydrogen atom or a residue of an amino acid derivative which is bonded to N atom through carbonyl group) to a peptide C-terminal α-hydroxyglycine adduct represented by the following formula (II): (wherein A and X have the same meanings as above), and further catalyzing the conversion of the peptide C-terminal α-hydroxylglycine adduct represented by the above formula (II) to a C-terminal amidated compound represented by the following formula (III): (wherein A and X have the see meanings as defined above), which comprises culturing host cells transformed with an expression plasmid comprising a DNA coding for said enzyme, and recovering both or either of said enzymes from the culture, characterized in that in said DNA a portion corresponding to the membrane spanning region has been excised.

  催化下式（I）所代表的肽 C 端甘氨酸加合物转化的酶： (其中 A 代表α-氨基或亚胺基和α-羧基以外的残基，α-氨基或亚胺基和α-羧基来自天然存在的α-氨基酸，X 代表氢原子或通过羰基与 N 原子结合的氨基酸衍生物残基)转化为下式(II)代表的肽 C-末端α-羟基甘氨酸加合物： (其中A和X的含义同上)，并进一步催化由上式(II)代表的肽C-末端α-羟基甘氨酸加合物转化为由下式(III)代表的C-末端酰胺化化合物： (其中A和X的含义与上式相同)，其中包括培养用包含编码上述酶的DNA的表达质粒转化的宿主细胞，并从培养物中回收上述两种或其中一种酶，其特征在于，在上述DNA中，对应于跨膜区的部分已被切除。
• Method for producing of phthalocyanine compound
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0882768A2

  公开（公告）日：1998-12-09

  A method for producing a novel phthalocyanine compound which excels in yield and purity, allows no introduction of a chlorine atom into the phthalocyanine skeleton, and possesses relatively bulky substituents is provided. This method is characterized by causing an orthophthalonitrile compound having a substituent exhibiting smaller σp values than σm values in the Hammett's rule to react with a metal oxide in the presence of a compound forming in the aqueous solution thereof at 25°C an acid or conjugate acid having a dissociation index pKa (the logarithmic value of the reciprocal of the dissociation constant of the acid or conjugate acid) of not more than 7.0.

  本发明提供了一种生产新型酞菁化合物的方法，该方法产量高、纯度高，不允许在酞菁骨架中引入氯原子，并具有相对笨重的取代基。 该方法的特点是，在 25°C 时，在其水溶液中形成的酸或共轭酸的化合物存在下，使具有取代基的 σp 值小于哈密特规则中的σm 值的邻苯二甲腈化合物与金属氧化物反应，该酸或共轭酸的离解指数 pKa（酸或共轭酸的离解常数倒数的对数值）不大于 7.0。
• Enzyme participating in C-terminal amidation, and method of preparing same and use thereof
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0884389A1

  公开（公告）日：1998-12-16

  An enzyme participating in C-terminal amidation which acts on a peptide C-terminal glycine adduct represented by the following formula (I): (wherein A represents a residue other than α-amino group or imino group and α-carboxylic group derived from naturally occurring α-amino acid, X represents hydrogen atom or a residue of an amino acid derivative which is bonded to N atom through carbonyl group) to form a peptide C-terminal α-hydroxylglycine adduct represented by the following formula (II): (wherein A and X have the same meanings as above, and an enzyme participating in peptide C-terminal amidation of a peptide terminal glycine adduct which acts on a peptide C-terminal α-hydroxylglycine adduct represented by the above formula (II) to form a C-terminal amidated compound represented by the following formula (III): (wherein A and X have the same meanings as described above) a method of producing the same, and the use thereof.

  一种参与 C 端酰胺化的酶，它作用于由下式（I）代表的肽 C 端甘氨酸加合物： (其中 A 代表α-氨基或亚胺基和α-羧基以外的残基，X 代表氢原子或通过羰基与 N 原子结合的氨基酸衍生物残基），以形成下式（II）所代表的肽 C-末端α-羟基甘氨酸加合物： (其中 A 和 X 的含义同上，以及一种参与肽 C-末端甘氨酸加合物酰胺化的酶，该酶作用于上式(II)代表的肽 C-末端α-羟基甘氨酸加合物，形成下式(III)代表的 C-末端酰胺化化合物： (其中A和X的含义与上述相同）的生产方法及其用途。
• Cellulose acetate and dope containing the same
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP0943626A1

  公开（公告）日：1999-09-22

  Using the dope containing the following cellulose acetate (1), (2), or (3), a film is prepared by the casting process: (1) a cellulose acetate having carboxyl groups binding to at least one member selected from the group consisting of a cellulose acetate and a hemicellulose acetate, wherein at least a part of said carboxyl groups are in an acidic form; (2) a cellulose acetate containing at least one member selected from the group consisiting of an acid having an acid dissociation exponent pKa of 1.93 to 4.50 in water, an alkali metal salt of said acid and an alkaline earth metal of said acid; or (3) a cellulose acetate containing an alkali metal or an alkaline earth metal wherein the total content of an alkaline metal and an alkaline earth metal in 1 gram of the cellulose acetate is from an effective amount to 5.5 x 10-6 equivalent (in terms of ion equivalent). The above cellulose acetate is also useful for spinning process. The cellulose acetate includes a cellulose diacetate and a cellulose triacetate. The cellulose acetate of the present invention has high film-releasability from a support and excellent optical characteristics.

  使用含有以下醋酸纤维素 (1)、(2) 或 (3) 的涂料，通过浇铸工艺制备薄膜： (1) 具有羧基的醋酸纤维素，羧基与至少一个选自醋酸纤维素和醋酸半纤维素的成员结合，其中至少一部分羧基呈酸性； (2) 含有至少一个成员的醋酸纤维素，该成员选自由在水中的酸解离指数 pKa 为 1.93 至 4.50 的酸、所述酸的碱金属盐和所述酸的碱土金属组成的组；或 (3) 含有碱金属或碱土金属的醋酸纤维素，其中 1 克醋酸纤维素中碱金属和碱土金属的总含量为有效量至 5.5 x 10-6 当量（以离子当量计）。上述醋酸纤维素还可用于纺丝工艺。醋酸纤维素包括二醋酸纤维素和三醋酸纤维素。本发明的醋酸纤维素具有很高的从载体中释放薄膜的能力和优异的光学特性。