6-bromo-2-(3,4-diethoxyphenyl)-3-nitro-2H-chromene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6-bromo-2-(3,4-diethoxyphenyl)-3-nitro-2H-chromene
• 化学式: C19H18BrNO5
• 分子量: 420.3
• InChiKey: MLTNUTWAVASJRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  73.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
  申请人：UNIVERSITY OF SOUTH CAROLINA

  公开号：US11059842B2

  公开（公告）日：2021-07-13

  Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.

  本研究提供了对克氏原虫寄生虫具有生物活性的抑制剂化合物及其使用方法。这些化合物可用于强效抑制原生动物寄生虫中发现的关键药物靶标，例如靶标克氏锥虫葡萄糖激酶。化合物包括 3-硝基-2-苯基-2H-色烯的衍生物，以及单糖胺，包括 D-氨基葡萄糖、D-氨基甘露糖、D-半乳糖胺和 D-果糖胺。
• Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases
  申请人：UNIVERSITY OF SOUTH CAROLINA

  公开号：US20200339619A1

  公开（公告）日：2020-10-29

  Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.