N-(4-methoxyphenyl)pyrimidin-5-amine | 1372770-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(4-methoxyphenyl)pyrimidin-5-amine
• CAS: 1372770-98-3
• 化学式: C₁₁H₁₁N₃O
• 分子量: 201.228
• InChiKey: HXOTVLJMZRKOBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-氨基嘧啶 、 4-溴苯甲醚 在 (2,4-环戊二烯-1-基)(苯基-2-丙烯基)-钯 、 sodium t-butanolate 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 甲苯 为溶剂， 以87%的产率得到N-(4-methoxyphenyl)pyrimidin-5-amine
  参考文献：
  名称：

  高反应活性的吡啶和嘧啶二芳基胺抗氧化剂的制备

  摘要：

  我们最近报告了对开发新型二芳基胺自由基捕获抗氧化剂（汉索恩（JJ）等。J.上午 化学 Soc。 2012，134（8306-8309），其中我们证明了将环氮掺入二苯胺中可提供在H原子对过氧自由基的转移反应性与对单电子氧化的稳定性之间折衷的化合物。本文中，我们提供了与该报告相关的合成研究的详细信息，已对其进行了实质性扩展，以生成取代的杂环二芳基胺库，我们已使用该库进一步了解了这些化合物作为抗氧化剂的结构-反应性关系（请参阅随附的纸张，DOI：10.1021 / jo301012x）。简而言之，制备了二芳基胺 由2-氨基吡啶和2-氨基嘧啶组成的模块序列，其中中间体吡啶（mi）dyl溴化物的胺化以及然后Pd催化的胺与前体溴化物的交叉偶联反应是生成二芳基胺的关键步骤。发现交叉偶联反应在Pd（η3 -1-PHC 3 ħ 4）（η 5 -C 5 H ^ 5）作为前段催化剂，这给了比常规的Pd源，钯更高的产量2（DBA）3。

  DOI：

  10.1021/jo301013c

文献信息

• Leuco colorants as bluing agents in laundry care compositions
  申请人：The Procter & Gamble Company

  公开号：US11136535B2

  公开（公告）日：2021-10-05

  A laundry care composition comprising: (a) at least one laundry care ingredient, (b) a leuco composition; (c) a stabilizing amount of an antioxidant composition which comprises at least one phenol selected from the group consisting of alkylated phenol, hindered phenol, and mixtures thereof and at least one substituted diarylamine, wherein the mole ratio of the phenol to the substituted diarylamine is greater than 1:1.

  一种衣物护理组合物，包括：(a) 至少一种衣物护理成分；(b) 一种洗衣剂组合物；(c) 一种稳定量的抗氧化剂组合物，该抗氧化剂组合物包括至少一种选自烷基化苯酚、受阻苯酚及其混合物的苯酚和至少一种取代的二芳基胺，其中苯酚与取代的二芳基胺的摩尔比大于 1:1。
• Stabilized compositions comprising leuco compounds
  申请人：Milliken & Company

  公开号：US11261403B2

  公开（公告）日：2022-03-01

  A composition comprising: (a) a leuco composition; and (b) a stabilizing amount of an antioxidant composition. The antioxidant composition comprises at least one sterically hindered phenol and at least one substituted diarylamine, and the mole ratio of the hindered phenol to the substituted diarylamine is greater than 1:1. In another embodiment, a composition comprises (a) a leuco composition and (b) an antioxidant composition; and optionally (c) a solvent composition. The combined mass of the leuco compounds and antioxidants present in the composition is 10% or more of the total mass of the composition, and (b) the molar ratio of antioxidants present in the composition to leuco compounds present in the composition is greater than 1:1.

  一种组合物，包括：(a)一种白蛋白组合物；和(b)一种稳定量的抗氧化剂组合物。抗氧化剂组合物包括至少一种立体受阻酚和至少一种取代的二芳基胺，受阻酚与取代的二芳基胺的摩尔比大于 1:1。在另一个实施方案中，组合物包括：(a) 白亮组合物和 (b) 抗氧化剂组合物；以及 (c) 溶剂组合物。组合物中存在的月桂化合物和抗氧化剂的总质量占组合物总质量的 10%或以上，且(b) 组合物中存在的抗氧化剂与组合物中存在的月桂化合物的摩尔比大于 1:1。
• LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS
  申请人：The Procter & Gamble Company

  公开号：EP3830232A1

  公开（公告）日：2021-06-09
• STABILIZED COMPOSITIONS COMPRISING LEUCO COMPOUNDS
  申请人：Milliken & Company

  公开号：US20200032167A1

  公开（公告）日：2020-01-30

  A composition comprising: (a) a leuco composition; and (b) a stabilizing amount of an antioxidant composition. The antioxidant composition comprises at least one sterically hindered phenol and at least one substituted diarylamine, and the mole ratio of the hindered phenol to the substituted diarylamine is greater than 1:1. In another embodiment, a composition comprises (a) a leuco composition and (b) an antioxidant composition; and optionally (c) a solvent composition. The combined mass of the leuco compounds and antioxidants present in the composition is 10% or more of the total mass of the composition, and (b) the molar ratio of antioxidants present in the composition to leuco compounds present in the composition is greater than 1:1.
• [EN] LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS<br/>[FR] COLORANTS LEUCO UTILISÉS COMME AGENTS D'AZURAGE DANS DES COMPOSITIONS D'ENTRETIEN DU LINGE
  申请人：PROCTER & GAMBLE

  公开号：WO2020023812A1

  公开（公告）日：2020-01-30

  A laundry care composition comprising: (a) at least one laundry care ingredient, (b) a leuco composition; (c) a stabilizing amount of an antioxidant composition which comprises at least one phenol selected from the group consisting of alkylated phenol, hindered phenol, and mixtures thereof and at least one substituted diarylamine, wherein the mole ratio of the phenol to the substituted diarylamine is greater than 1:1.