(tert-butyldiphenylsilyl)(4-methoxyphenyl)methanol | 1369432-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (tert-butyldiphenylsilyl)(4-methoxyphenyl)methanol
• 英文别名: [Tert-butyl(diphenyl)silyl]-(4-methoxyphenyl)methanol；[tert-butyl(diphenyl)silyl]-(4-methoxyphenyl)methanol
• CAS: 1369432-39-2
• 化学式: C₂₄H₂₈O₂Si
• 分子量: 376.571
• InChiKey: CQUOKVKQUWKKBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.33
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (tert-butyldiphenylsilyl)(4-methoxyphenyl)methanol 在 silica gel 作用下， 生成 t-butyl diphenylsilanol 、 4-甲氧基苄醇
  参考文献：
  名称：

  A Lewis acid-promoted reduction of acylsilanes to α-hydroxysilanes by diethylzinc

  摘要：

  We report here the first example of the reduction of acylsilanes to alpha-hydroxysilanes, in which diethylzinc was used as a highly reactive agent in the presence of Ti(OiPr)(4) or other Lewis acids. The reduction typically proceeds to give synthetically useful alpha-hydroxysilanes in good yields. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.059
• 作为产物：
  描述：

  在 titanium(IV) isopropylate 、 diethylzinc 、 盐酸 作用下， 以 乙醚 、 正己烷 、 水 为溶剂， 反应 12.0h， 以35%的产率得到(tert-butyldiphenylsilyl)(4-methoxyphenyl)methanol
  参考文献：
  名称：

  A Lewis acid-promoted reduction of acylsilanes to α-hydroxysilanes by diethylzinc

  摘要：

  We report here the first example of the reduction of acylsilanes to alpha-hydroxysilanes, in which diethylzinc was used as a highly reactive agent in the presence of Ti(OiPr)(4) or other Lewis acids. The reduction typically proceeds to give synthetically useful alpha-hydroxysilanes in good yields. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.059

文献信息

• A Lewis acid-promoted reduction of acylsilanes to α-hydroxysilanes by diethylzinc
  作者：Guang Gao、Xing-Feng Bai、Fei Li、Long-Sheng Zheng、Zhan-Jiang Zheng、Guo-Qiao Lai、Kezhi Jiang、Fuwei Li、Li-Wen Xu

  DOI：10.1016/j.tetlet.2012.02.059

  日期：2012.4

  We report here the first example of the reduction of acylsilanes to alpha-hydroxysilanes, in which diethylzinc was used as a highly reactive agent in the presence of Ti(OiPr)(4) or other Lewis acids. The reduction typically proceeds to give synthetically useful alpha-hydroxysilanes in good yields. (c) 2012 Elsevier Ltd. All rights reserved.