ANA-12抑制剂 | 219766-25-3

• 物质功能分类: 生物化工 - 抑制剂 - 蛋白酪氨酸激酶
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 中文名称: ANA-12抑制剂
• 中文别名: N-2-（六氢-2-氧代-1H-氮杂卓-3-基）氨基羰基苯基-苯并b噻吩-2-甲酰胺；化合物ANA-12；N-(2-((2-氧代氮杂环庚烷-3-基)氨甲酰)苯基)苯并噻吩-2-甲酰胺；N-[2-[[(六氢-2-氧代-1H-氮杂卓-3-基)氨基]羰基]苯基]苯并[B]噻吩-2-甲酰胺
• 英文名称: N-[2-[(2-oxoazepan-3-yl)carbamoyl]phenyl]-1-benzothiophene-2-carboxamide
• CAS: 219766-25-3
• 化学式: C₂₂H₂₁N₃O₃S
• 分子量: 407.5
• InChiKey: TUSCYCAIGRVBMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Treatment of impaired cognitive flexibility with TrkB receptor antagonists
  申请人：Florida State University Research Foundation, Inc.

  公开号：US10245271B2

  公开（公告）日：2019-04-02

  The cognitive flexibility of a subject may be improved by administering a therapeutically effective amount of a TrkB receptor antagonist to the subject in need thereof. The TrkB receptor antagonist compound may be administered in a pharmaceutical dosage form.

  通过向有需要的受试者施用治疗有效量的 TrkB 受体拮抗剂，可以改善受试者的认知灵活性。TrkB受体拮抗剂化合物可以药物剂型给药。
• Treatment of Impaired Cognitive Flexibility with TrkB Receptor Antagonists
  申请人：Florida State University Research Foundation, Inc.

  公开号：US20170020888A1

  公开（公告）日：2017-01-26

  The cognitive flexibility of a subject may be improved by administering a therapeutically effective amount of a TrkB receptor antagonist to the subject in need thereof. The TrkB receptor antagonist compound may be administered in a pharmaceutical dosage form.
• COMPOSITIONS AND METHODS FOR TREATING REFRACTORY SEIZURES
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20170281579A1

  公开（公告）日：2017-10-05

  The present invention relates to the field of seizures. More specifically, the present invention provides compositions and methods for treating refractory seizures in neonates. In one embodiment, the method comprises the steps of (a) administering to the patient an amount of a KCC2 agonist and/or trkB antagonist effective to restore KCC2 expression to normal physiological levels; and (b) administering to the patient an effective amount of an anti-seizure medication.
• [EN] COMPOSITIONS AND METHODS FOR TREATING REFRACTORY SEIZURES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE CRISES D'ÉPILEPSIE RÉFRACTAIRE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2016025778A1

  公开（公告）日：2016-02-18

  The present invention relates to the field of seizures. More specifically, the present invention provides compositions and methods for treating refractory seizures in neonates. In one embodiment, the method comprises the steps of (a) administering to the patient an amount of a KCC2 agonist and/or trkB antagonist effective to restore KCC2 expression to normal physiological levels; and (b) administering to the patient an effective amount of an anti-seizure medication.