[EN] COMPOUNDS AND METHODS FOR PURIFICATION OF SERINE PROTEASES<br/>[FR] COMPOSÉS ET PROCÉDÉS DE PURIFICATION DE SÉRINE PROTÉASES
申请人:PORTOLA PHARM INC
公开号:WO2014106128A1
公开(公告)日:2014-07-03
Disclosed herein are compounds, compositions, methods and kits for purifying a protease and serine proteases purified with the compounds, compositions and methods.
[EN] METHODS OF SYNTHESIZING FACTOR XA INHIBITORS<br/>[FR] PROCÉDÉS DE SYNTHÈSE D'INHIBITEURS DU FACTEUR XA
申请人:MILLENNIUM PHARM INC
公开号:WO2011084519A1
公开(公告)日:2011-07-14
Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
[EN] ISOTOPICALLY ENRICHED BETRIXABAN<br/>[FR] BÉTRIXABAN ENRICHI EN ISOTOPES
申请人:PORTOLA PHARM INC
公开号:WO2017091757A1
公开(公告)日:2017-06-01
Described herein are deuterated analogs of betrixaban, pharmaceutical compositions comprising the same, and methods of using the same.
本文描述了贝曲班的氘代物、包含该氘代物的药物组合物,以及使用该氘代物的方法。
[EN] CRYSTALLINE FORMS OF A FACTOR Xa INHIBITOR<br/>[FR] FORMES CRISTALLINES D'UN INHIBITEUR DU FACTEUR XA
申请人:PORTOLA PHARM INC
公开号:WO2012031017A1
公开(公告)日:2012-03-08
Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.
本文提供了贝特利昔班马来酸盐的晶体形式、组成物及其制备或使用方法。
METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS
申请人:Millennium Pharmaceuticals, Inc.
公开号:US20130211094A1
公开(公告)日:2013-08-15
Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.