Boc-DL-天冬氨酸 | 120341-32-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: Boc-DL-天冬氨酸
• 英文名称: N-Boc-aspartic acid
• 英文别名: 2-[(2-methylpropan-2-yl)oxycarbonylamino]butanedioic acid
• CAS: 120341-32-4
• 化学式: C₉H₁₅NO₆
• 分子量: 233.221
• InChiKey: KAJBMCZQVSQJDE-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C
• 沸点：
  377.4±32.0 °C(Predicted)
• 密度：
  1.302±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  Boc-DL-天冬氨酸 在 sodium hypochlorite 作用下， 以 甲醇 、 水 为溶剂， 反应 30.0h， 以15%的产率得到Boc-ΔAla-OH
  参考文献：
  名称：

  Seki, Masahiko; Moriya, Tamon; Matsumoto, Kazuo, Agricultural and Biological Chemistry, 1984, vol. 48, # 5, p. 1251 - 1256

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-oxobutanoic acid 以 甲醇 、 二氯甲烷 为溶剂， 生成 Boc-DL-天冬氨酸
  参考文献：
  名称：

  A convenient and rapid method for the selective oxygen-17 enrichment of aspartyl peptides during solid-phase synthesis

  摘要：

  In this work we describe, for the first time, a rapid and efficient method for O-17 selective labeling on the beta -carboxyl group of an aspartic acid residue already incorporated into a peptide sequence anchored on a solid-phase support. The beta -O-benzyl ester of the Asp residue of the Ac-RGD-benzydrylamine resin was successfully saponified using (NaOH)-O-17 in a methanol/ dichloromethane mixture. The O-17 selective enriched peptide was then released from the solid support by acidic cleavage. The O-17 NMR spectrum confirmed the O-17 labeling of the Asp beta -carboxylate. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01632-x

文献信息

• [EN] ANTI-INFLUENZA COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS ANTI-GRIPPE ET PROCÉDÉS ASSOCIÉS
  申请人：BIOCRYST PHARM INC

  公开号：WO2014186465A1

  公开（公告）日：2014-11-20

  Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.

  揭示了一种新颖的化合物，包括一种亚胺-核糖衍生物与一个碳环或杂环共价连接。还描述了包括该发明化合物的药物组合物。还描述了使用该发明化合物抑制、治疗和/或抑制病毒感染的方法。这些组合物或方法可以选择性地包括一种或多种额外的抗病毒药物。
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2017099823A1

  公开（公告）日：2017-06-15

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  这项披露提供了改进的基于脂质的组合物，包括脂质纳米粒子组合物，以及它们用于体内传递药剂的方法，包括核酸和蛋白质。这些组合物不受加速血清清除的影响，并且它们在体内具有改进的毒性特性。
• Reagents and methods for esterification
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10577303B1

  公开（公告）日：2020-03-03

  A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: wherein the R1 and R2 groups of the diazo compound are selected such that the corresponding organic compound of formula: exhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins.

  一种酯化方法，用于含有一个或多个羧酸基团的化合物中一个或多个羧酸基团的酯化，其中酯化试剂是具有以下结构的重氮化合物： 其中重氮化合物的R1和R2基团被选择为使相应的有机化合物具有在DMSO中测得的—C—H pKa值在18和29之间。提供了用于酯化的特定试剂和方法。所提供的酯化试剂对含有一个或多个羧酸基团的化合物中的羧酸基团的酯化表现出高选择性，而不与胺基、醇基或硫醇基反应。该方法可用于选择性地酯化肽或蛋白质中的羧酸基团。
• TACN-based cationic lipids with amino acid backbone and double tails: Materials for non-viral gene delivery
  作者：Bing Wang、Wen-Jing Yi、Ji Zhang、Qin-Fang Zhang、Miao-Miao Xun、Xiao-Qi Yu

  DOI：10.1016/j.bmcl.2014.02.034

  日期：2014.4

  Cationic lipids have become an efficient type of non-viral vectors for gene delivery. In this Letter, four cationic lipids containing 1,4,7-triazacyclononane (TACN) headgroup, glutamic/aspartic acid backbone and dioleyl tails were designed and synthesized. The TACN headgroup gives these lipids excellent pH buffering capacities, which were higher than branched 25kDa PEI. Cationic liposomes prepared from

  阳离子脂质已成为一种有效的基因传递非病毒载体。在这封信中，设计并合成了四种含有 1,4,7-三氮杂环壬烷 (TACN) 头基、谷氨酸/天冬氨酸主链和二油基尾部的阳离子脂质。 TACN 头基赋予这些脂质优异的 pH 缓冲能力，高于支链 25kDa PEI。由这些脂质和DOPE制备的阳离子脂质体表现出良好的DNA亲和力，并且通过琼脂糖凝胶电泳发现在/比为3时DNA完全凝聚。通过动态光散射 (DLS) 测定对脂质复合物进行表征，该测定给出了适合转染的颗粒大小和 zeTA 电位。两种细胞系的体外基因转染结果表明（结构中含有天冬氨酸和酰胺键）表现出最佳的转染效率，接近市售转染剂LipofecTAmine 2000。
• Heteroarylpyrrolopyridinones active as kinase inhibitors
  申请人：Vanotti Ermes

  公开号：US20070142415A1

  公开（公告）日：2007-06-21

  Compounds represented by formula (I) wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification or a pharmaceutically acceptable salt or solvate thereof, compositions thereof, and methods of use thereof.

  由式（I）表示的化合物 其中A，R1，R2，R3，R4，R5和R6如规范中定义，或其药用可接受盐或溶剂，其组合物和使用方法。