(2-(3-methoxyphenyl)allyl)(trifluoromethyl)sulfane | 1421842-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2-(3-methoxyphenyl)allyl)(trifluoromethyl)sulfane
• 英文别名: (2-(3-methoxylphenyl)allyl)(trifluoromethyl)sulfane；1-Methoxy-3-[3-(trifluoromethylsulfanyl)prop-1-en-2-yl]benzene；1-methoxy-3-[3-(trifluoromethylsulfanyl)prop-1-en-2-yl]benzene
• CAS: 1421842-39-8
• 化学式: C₁₁H₁₁F₃OS
• 分子量: 248.269
• InChiKey: JDZLLEWMSMPPSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-苯基-S-(三氟甲基)硫代羟胺 、 (2-(3-methoxyphenyl)allyl)trimethylsilane 在 乙酰氯 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 10.0h， 以80%的产率得到(2-(3-methoxyphenyl)allyl)(trifluoromethyl)sulfane
  参考文献：
  名称：

  Electrophilic Trifluoromethylthiolation of Allylsilanes with Trifluoromethanesulfanamide

  摘要：

  A CH3COCl-promoted allylic trifluoromethylthiolation of allylsilanes with trifluoromethanesulfanamide has been described. The method allows for an efficient synthesis of a wide range of allylic trifluoromethylthiolated compounds under mild conditions.

  DOI：

  10.1021/ol400032g

文献信息

• Trifluoromethylthiolation of Allylsilanes and Silyl Enol Ethers with Trifluoromethanesulfonyl Hypervalent Iodonium Ylide under Copper Catalysis
  作者：Sadayuki Arimori、Masahiro Takada、Norio Shibata

  DOI：10.1021/acs.orglett.5b00057

  日期：2015.3.6

  Electrophilic trifluoromethylthiolation of allylsilanes and silyl enol ethers with trifluoromethanesulfonyl hypervalent iodonium ylide has been conducted. In the presence of a catalytic amount of CuF2, the reaction proceeded in modest to high yields under mild conditions.

  已经进行了烯丙基硅烷和甲硅烷基烯醇醚与三氟甲磺酰基高价碘鎓叶立德的亲电子三氟甲基硫醇化反应。在催化量的CuF 2的存在下，反应在温和的条件下以中等至高收率进行。
• Electrophilic Trifluoromethylthiolation of Allylsilanes with Trifluoromethanesulfanamide
  作者：Jianbo Liu、Lingling Chu、Feng-Ling Qing

  DOI：10.1021/ol400032g

  日期：2013.2.15

  A CH3COCl-promoted allylic trifluoromethylthiolation of allylsilanes with trifluoromethanesulfanamide has been described. The method allows for an efficient synthesis of a wide range of allylic trifluoromethylthiolated compounds under mild conditions.