US10610125, Example Table 24a.2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: US10610125, Example Table 24a.2
• 英文别名: 3-[4-[5-(4-methylphenyl)-2-phenyl-3,4-dihydropyrazol-3-yl]-3-phenylpyrazol-1-yl]propanoic acid
• 化学式: C₂₈H₂₆N₄O₂
• 分子量: 450.5
• InChiKey: WLFJKBNDGHVXMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  70.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods and compositions for cell-proliferation-related disorders
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US10610125B2

  公开（公告）日：2020-04-07

  Methods of treating and evaluating subjects having neoactive mutants are described herein.

  本文描述了治疗和评估具有新活性突变体的受试者的方法。
• METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS
  申请人：Dang Leonard Luan C

  公开号：US20150240286A1

  公开（公告）日：2015-08-27

  Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).

  治疗和评估具有IDH新活性突变体（例如IDH1或IDH2）的受试者的方法。
• Methods for diagnosing IDH-mutant cell proliferation disorders
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US10711314B2

  公开（公告）日：2020-07-14

  Methods of diagnosing subjects having a cell proliferation-related disorder or suspected of having a cell proliferation-related disorder associated with mutant IDH enzymes with 2HG neoactivity.

  诊断患有细胞增殖相关疾病或疑似患有细胞增殖相关疾病的受试者与具有 2HG 新生活性的突变 IDH 酶有关的方法。
• METHODS FOR CELL-PROLIFERATION-RELATED DISORDERS
  申请人：Les Laboratoires Servier

  公开号：EP3561077B1

  公开（公告）日：2022-12-21
• METHODS AND COMPOSITONS FOR CELL-PROLIFERATION-RELATED DISORDERS
  申请人：Su Shin-San Michael

  公开号：US20130183281A1

  公开（公告）日：2013-07-18

  Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).