(3-But-3-enyl-3-methylcyclohexen-1-yl) trifluoromethanesulfonate | 1236206-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (3-But-3-enyl-3-methylcyclohexen-1-yl) trifluoromethanesulfonate
• CAS: 1236206-97-5
• 化学式: C₁₂H₁₇F₃O₃S
• 分子量: 298.326
• InChiKey: HZZPKWMWXDOHJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3-But-3-enyl-3-methylcyclohexen-1-yl) trifluoromethanesulfonate 、 (三甲基硅基)甲基氯化镁 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以93%的产率得到[(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane
  参考文献：
  名称：

  Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction

  摘要：

  A formal synthesis of (+/-)-axamide-1 and (+/-)-axisonitrile-1 was achieved by using an intramolecular Hosomi-Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a bicyclic compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.119
• 作为产物：
  描述：

  N-苯基双(三氟甲烷磺酰)亚胺 、 以 乙醚 为溶剂， 反应 12.0h， 生成 (3-But-3-enyl-3-methylcyclohexen-1-yl) trifluoromethanesulfonate
  参考文献：
  名称：

  Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction

  摘要：

  A formal synthesis of (+/-)-axamide-1 and (+/-)-axisonitrile-1 was achieved by using an intramolecular Hosomi-Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a bicyclic compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.119