methyl 2-(dimethoxyphosphoryl)-3-(furan-2-yl)acrylate | 907547-11-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 2-(dimethoxyphosphoryl)-3-(furan-2-yl)acrylate
• 英文别名: Methyl 2-dimethoxyphosphoryl-3-(furan-2-yl)prop-2-enoate
• CAS: 907547-11-9
• 化学式: C₁₀H₁₃O₆P
• 分子量: 260.183
• InChiKey: QAAQMJIHZOHTPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  75
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  吡咯 、 methyl 2-(dimethoxyphosphoryl)-3-(furan-2-yl)acrylate 在 Montmorillonite K-10 作用下， 反应 48.0h， 以25%的产率得到methyl 2-(dimethoxyphosphoryl)-3-(furan-2-yl)-3-(1H-pyrrol-2-yl)propanoate
  参考文献：
  名称：

  Michael Addition of N-Heteroaromatics to Vinylphosphonates and Synthesis of Phosphoryl Pyrrolizones by Cyclization of Michael Adducts

  摘要：

  Novel phosphonate compounds were synthesized via Michael addition of N-heteroaromatic compounds to aryl-and alkyl-substituted vinylphosphonates using scandium triflate as the catalyst. Intramolecular cyclization reaction of the Michael adducts obtained gives novel (dimethoxyphosphoryl) pyrrolizin-3-ones in high yields as a single diastereomer.

  DOI：

  10.1055/s-0032-1317894

文献信息

• Michael Addition of N-Heteroaromatics to Vinylphosphonates and Synthesis of Phosphoryl Pyrrolizones by Cyclization of Michael Adducts
  作者：Canan Unaleroglu、Dilek Tasgin

  DOI：10.1055/s-0032-1317894

  日期：——

  Novel phosphonate compounds were synthesized via Michael addition of N-heteroaromatic compounds to aryl-and alkyl-substituted vinylphosphonates using scandium triflate as the catalyst. Intramolecular cyclization reaction of the Michael adducts obtained gives novel (dimethoxyphosphoryl) pyrrolizin-3-ones in high yields as a single diastereomer.