DL-丙氨酸钾 | 93893-38-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: DL-丙氨酸钾
• 英文名称: potassium alaninate
• 英文别名: α-alanine potassium salt；potassium aminopropionate；alanine potassium salt；potassium;2-aminopropanoate
• CAS: 93893-38-0
• 化学式: C₃H₆NO₂*K
• 分子量: 127.184
• InChiKey: UJLZCNZPJMYEKF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.91
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  DL-丙氨酸钾 、 4-(2-hydroxybenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one 以 乙醇 、 水 为溶剂， 反应 6.0h， 以71%的产率得到Potassium;2-[[3-(1-carboxyethylimino)-1,5-dimethyl-2-phenylpyrazol-4-yl]iminomethyl]phenolate
  参考文献：
  名称：

  DNA binding mode of novel tetradentate amino acid based 2-hydroxybenzylidene-4-aminoantipyrine complexes

  摘要：

  Few transition metal complexes of tetradentate N2O2 donor Schiff base ligands containing 2-hydroxybenzylidene-4-aminoantipyrine and amino acids (alanine/valine) abbreviated to KHL1/KHL2 have been synthesized. All the metal complexes have been fully characterized with the help of elemental analyses, molecular weights, molar conductance values, magnetic moments and spectroscopic data. The Schiff bases KHL1/KHL2 are found to act as tetradentate ligands using N2O2 donor set of atoms leading to a square-planar geometry for the complexes around the metal ions. The binding behaviors of the complexes to calf thymus DNA have been investigated by absorption spectra, viscosity measurements and cyclic voltammetry. The DNA binding constants reveal that all these complexes interact with DNA through minor groove binding mode. The studies on mechanism of photocleavage reveal that singlet oxygen (O-1(2)) and superoxide anion radical (O-2(center dot-)) may play an important role in the photocleavage. The Schiff bases and their metal complexes have been screened for their in vitro antibacterial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis, Klebsiella pneumoniae and antifungal activities against Aspergillus niger, Fusarium solani, Culvularia lunata, Rhizoctonia bataicola and Candida albicans by MIC method. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.07.051

文献信息

• Synthesis of [1]benzopyrano[4,3-b]pyrrol-4(1H)-ones from N(α)-(2-oxo-2H-1-benzopyran-4-yl)weinreb α-aminoamides
  作者：Angel Alberola、Rocío Álvaro、Alfonso González Ortega、M.Luisa Sádaba、M Carmen Sañudo

  DOI：10.1016/s0040-4020(99)00802-9

  日期：1999.11

  were prepared from 4-chlorocoumarin and α-aminoacid derivatives. Their reaction with organometallic compounds (RLi or RMgBr) and subsequent cyclization of ketones thus obtained, give [1]benzopyrano[4,3-b]pyrrol-4(1H)-ones. Starting from proline derivatives, simultaneously with the pyranone-pyrrole fusion, we establish an interesting procedure for the formation of pyrrolizines.

  由4-氯香豆素和α-氨基酸衍生物制得N（α）-（2-Oxo-2 H -1-苯并吡喃-4-基）Weinreb-α-氨基酰胺。它们与有机金属化合物（RLi或RMgBr）反应，然后将如此得到的酮环化，得到[1]苯并吡喃并[4,3 - b ]吡咯-4（1 H）-。从脯氨酸衍生物开始，与吡喃酮-吡咯融合同时，我们建立了一个有趣的过程，用于形成吡咯嗪。
• Phospholidines incorporating a β N-sulfonylaminoalcohol moiety: first observed selectivity of phosphorus heterocycle aminolysis in the presence of water
  作者：Frédéric Dujols、Laurence Marty、Michel Mulliez

  DOI：10.1039/b415285a

  日期：——

  Eleven 2-oxo or 2-thioxo 3-sulfonyl 1,3,2-oxazaphospholidines were synthesized in one step by condensing P(IV) dichlorides with N-sulfonyl-ethanolamines, or -aminothexylalcohols or -ortho-aminophenols. These compounds, in contrast to all other phosphorus heterocycles studied so far, reacted easily with amines, sometimes selectively in the presence of water, leading to the corresponding amides. The results are rationalized by the involvement of the addition–elimination mechanism of phosphorylation with direct collapse of the primary zwitterionic intermediate formed by the amine attack on phosphorus

  通过将P(IV)二氯化物与N-磺酰乙醇胺、-氨基六醇或-邻氨基酚缩合，一步合成了十一种2-氧或2-硫氧的3-磺酰基1,3,2-氧氮杂磷环化合物。这些化合物与迄今为止研究的所有其他磷杂环化合物相比，容易与胺反应，有时在水存在的情况下选择性反应，生成相应的酰胺。结果可以通过磷酸化的加成－消除机制来解释，其中在胺攻击磷产生的初级双性离子中间体直接崩溃。
• Imines derived from 4-methyl-4-diphenylphosphorylpentan-2-one and potassium salts of aminocarboxylic acids
  作者：M. N. Dimukhametov、V. F. Mironov、D. A. Tatarinov

  DOI：10.1134/s1070363217040363

  日期：2017.4

  An effective procedure for the preparation of imines based on 4-methyl-4-diphenylphosphorylpentan-2-one, aminoacetic, aminopropionic, and aminobutyric acids with yields of 90–95% was developed. Reaction of dimephosphone (4-methyl-4-dimethoxyphosphorilpentan-2-one) with potassium salts of these amino acids led to methylation of the carboxy group of the amino acid to form potassium salt of 2-methyl-

  开发了一种有效的制备基于4-甲基-4-二苯基磷酰基戊基-2-酮，氨基乙酸，氨基丙酸和氨基丁酸的亚胺的方法，产率为90-95％。二甲基膦（4-甲基-4-二甲氧基磷杂戊基-2-酮）与这些氨基酸的钾盐的反应导致氨基酸的羧基甲基化，从而形成2-甲基-4-氧戊基膦酸甲酯的钾盐。
• Buzykin, B. I.; Sokolov, M. P., Journal of general chemistry of the USSR, 1990, vol. 60, # 9.1., p. 1767 - 1772
  作者：Buzykin, B. I.、Sokolov, M. P.

  DOI：——

  日期：——
• Patel, Pushpa; Bhattacharya, P K, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1993, vol. 32, # 6, p. 506 - 510
  作者：Patel, Pushpa、Bhattacharya, P K

  DOI：——

  日期：——