(R)-tert-butyl [1-(5-bromo-2-fluorophenyl)-2-(4-chloro-2-cyano-1H-imidazol-1-yl)-1-methylethyl]carbamate | 1383742-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-tert-butyl [1-(5-bromo-2-fluorophenyl)-2-(4-chloro-2-cyano-1H-imidazol-1-yl)-1-methylethyl]carbamate
• 英文别名: tert-butyl N-[(2R)-2-(5-bromo-2-fluorophenyl)-1-(4-chloro-2-cyanoimidazol-1-yl)propan-2-yl]carbamate
• CAS: 1383742-29-7
• 化学式: C₁₈H₁₉BrClFN₄O₂
• 分子量: 457.73
• InChiKey: LVFSPGQMRSVLAR-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  79.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-chloro-1H-imidazole-2-carbonitrile 、 (4R)-4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylic acid 2,2-dioxide 1,1-dimethylethyl ester 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 盐酸 作用下， 以 乙腈 、 二氯甲烷 为溶剂， 反应 2.0h， 以98%的产率得到(R)-tert-butyl [1-(5-bromo-2-fluorophenyl)-2-(4-chloro-2-cyano-1H-imidazol-1-yl)-1-methylethyl]carbamate
  参考文献：
  名称：

  [EN] 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
  [FR] DÉRIVÉS 5,6-DIHYDRO-IMIDAZO[1,2-A]PYRAZIN-8-YLAMINE UTILES EN TANT QU'INHIBITEURS DE BÊTA SECRÉTASE (BACE)

  摘要：

  本发明涉及作为β-分泌酶抑制剂的新型5,6-二氢咪唑[1,2-a]吡嗪-8-胺衍生物，也称为β-位点淀粉样蛋白裂解酶、BACE、BACE1、Asp2或memapsin2。该发明还涉及包含这些化合物的药物组合物，用于制备这些化合物和组合物的方法，以及将这些化合物和组合物用于预防和治疗涉及β-分泌酶的疾病，如阿尔茨海默病（AD）、轻度认知障碍、老年痴呆、带有Lewy小体的痴呆、脑血管淀粉样血管病、多梗死性痴呆、唐氏综合征、与中风相关的痴呆、与帕金森病相关的痴呆或与β-淀粉样蛋白相关的痴呆。

  公开号：

  WO2012085038A1

文献信息

• 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
  申请人：Trabanco-Suárez Andres Avelino

  公开号：US20130274266A1

  公开（公告）日：2013-10-17

  The present invention relates to novel 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebrovascular amyloid angiopathy, multi-infarct dementia, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.

  本发明涉及一种新型的5,6-二氢咪唑[1,2-a]吡嗪-8-胺衍生物，作为β-分泌酶抑制剂，也称为β位点淀粉样蛋白裂解酶，BACE，BACE1，Asp2或memapsin2。该发明还涉及包含这些化合物的制药组合物，制备这些化合物和组合物的工艺，以及将这些化合物和组合物用于预防和治疗β-分泌酶参与的疾病，例如阿尔茨海默病（AD），轻度认知障碍，老年痴呆症，带有Lewy小体的痴呆症，脑血管淀粉样蛋白血管病，多发性梗死性痴呆，唐氏综合征，与中风相关的痴呆症，与帕金森病相关的痴呆症或与β-淀粉样蛋白相关的痴呆症。
• [EN] 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)<br/>[FR] DÉRIVÉS 5,6-DIHYDRO-IMIDAZO[1,2-A]PYRAZIN-8-YLAMINE UTILES EN TANT QU'INHIBITEURS DE BÊTA SECRÉTASE (BACE)
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012085038A1

  公开（公告）日：2012-06-28

  The present invention relates to novel 5,6-dihydro-imidazo[1,2-a]pyrazin-8- ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebrovascular amyloid angiopathy, multi- infarct dementia, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.

  本发明涉及作为β-分泌酶抑制剂的新型5,6-二氢咪唑[1,2-a]吡嗪-8-胺衍生物，也称为β-位点淀粉样蛋白裂解酶、BACE、BACE1、Asp2或memapsin2。该发明还涉及包含这些化合物的药物组合物，用于制备这些化合物和组合物的方法，以及将这些化合物和组合物用于预防和治疗涉及β-分泌酶的疾病，如阿尔茨海默病（AD）、轻度认知障碍、老年痴呆、带有Lewy小体的痴呆、脑血管淀粉样血管病、多梗死性痴呆、唐氏综合征、与中风相关的痴呆、与帕金森病相关的痴呆或与β-淀粉样蛋白相关的痴呆。