3,3'',4,4''-tetramethoxy-m-terphenyl | 1426236-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'',4,4''-tetramethoxy-m-terphenyl
• 英文别名: 4-[3-(3,4-Dimethoxyphenyl)phenyl]-1,2-dimethoxybenzene；4-[3-(3,4-dimethoxyphenyl)phenyl]-1,2-dimethoxybenzene
• CAS: 1426236-34-1
• 化学式: C₂₂H₂₂O₄
• 分子量: 350.414
• InChiKey: NZIILILHUQMTLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3'',4,4''-tetramethoxy-m-terphenyl 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 以91%的产率得到3,4,3'',4''-tetrahydroxy-m-terphenyl
  参考文献：
  名称：

  Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors

  摘要：

  3,3',4,4'-Tetrahydroxybiphenyl and three isomeric 3,3 '',4,4 ''-tetrahydroxyterphenyls with varying geometries around the central phenyl ring have been synthesized and evaluated for their in vitro activity against aggregation of Alzheimer's amyloid-beta peptide (A beta). Results from Congo red spectral-shift assays reveal that all four compounds successfully inhibit association of A beta monomers. For the tetrahydroxyterphenyls, efficacy varies with linker geometry: the ortho-arrangement affords the most successful inhibition and the para-geometry the least, perhaps due to differing abilities of these compounds to bind A beta. Of the four small molecules studied, 3,3',4,4'-tetrahydroxybiphenyl is the most effective inhibitor, reducing A beta aggregation by 50% when present in stoichiometric concentrations. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.076
• 作为产物：
  描述：

  1,3-二溴苯 、 3,4-二甲氧基苯硼酸 在 sodium carbonate 、 palladium dichloride 作用下， 以 乙醇 、 水 为溶剂， 反应 0.08h， 以76%的产率得到3,3'',4,4''-tetramethoxy-m-terphenyl
  参考文献：
  名称：

  Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors

  摘要：

  3,3',4,4'-Tetrahydroxybiphenyl and three isomeric 3,3 '',4,4 ''-tetrahydroxyterphenyls with varying geometries around the central phenyl ring have been synthesized and evaluated for their in vitro activity against aggregation of Alzheimer's amyloid-beta peptide (A beta). Results from Congo red spectral-shift assays reveal that all four compounds successfully inhibit association of A beta monomers. For the tetrahydroxyterphenyls, efficacy varies with linker geometry: the ortho-arrangement affords the most successful inhibition and the para-geometry the least, perhaps due to differing abilities of these compounds to bind A beta. Of the four small molecules studied, 3,3',4,4'-tetrahydroxybiphenyl is the most effective inhibitor, reducing A beta aggregation by 50% when present in stoichiometric concentrations. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.076

文献信息

• COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：JNC Corporation

  公开号：EP2842974A1

  公开（公告）日：2015-03-04

  The subject is to provide a polymerizable compound having a suitable polymerization reactivity, a high conversion yield and a high solubility in a liquid crystal composition. The subject is to provide a liquid crystal composition having physical properties such as a high maximum temperature of a nematic phase, a low minimum temperature of a nematic phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant, a large specific resistance and a suitable pretilt. The subject is to provide a liquid crystal display device containing the composition and having a wide temperature range in which the device can be used, a short response time, a large voltage holding ratio, a low threshold voltage, a large contrast ratio and a long service life. A compound represented by formula (1), a liquid crystal composition, a liquid crystal display device. In formula, for example, the ring A1 and the ring A4 are phenylene or cyclohexylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 6 carbons; L1 is a single bond; s and t are 0; and P1, P2, P3 and P4 are a polymerizable group.

  本课题旨在提供一种可聚合化合物，其在液晶组合物中具有合适的聚合反应性、高转化率和高溶解度。本发明的目的是提供一种液晶组合物，该液晶组合物具有如下物理性质：向 列相的最高温度高、向列相的最低温度低、粘度小、具有适当的光学各向异性、介 电各向异性大、具有适当的弹性常数、比电阻大和具有适当的前倾角。本发明的目的是提供一种含有该成分的液晶显示装置，该装置的使用温度范围宽、响应时间短、电压保持比大、阈值电压低、对比度大、使用寿命长。 一种由式（1）表示的化合物、一种液晶组合物、一种液晶显示装置。 例如在式中，环 A1 和环 A4 为亚苯基或环己基；Z1、Z2、Z3 和 Z4 为单键或具有 1 至 6 个碳原子的亚烷基；L1 为单键；s 和 t 为 0；P1、P2、P3 和 P4 为可聚合基团。
• COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC Corporation

  公开号：EP3199558A1

  公开（公告）日：2017-08-02

  The subject is to provide a polymerizable compound having a suitable polymerization reactivity, a high conversion yield and a high solubility in a liquid crystal composition. The subject is to provide a liquid crystal composition having physical properties such as a high maximum temperature of a nematic phase, a low minimum temperature of a nematic phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant, a large specific resistance and a suitable pretilt. The subject is to provide a liquid crystal display device containing the composition and having a wide temperature range in which the device can be used, a short response time, a large voltage holding ratio, a low threshold voltage, a large contrast ratio and a long service life.

  本课题旨在提供一种可聚合化合物，其在液晶组合物中具有合适的聚合反应性、高转化率和高溶解度。本发明的目的是提供一种液晶组合物，该液晶组合物具有如下物理性质：向 列相的最高温度高、向列相的最低温度低、粘度小、具有适当的光学各向异性、介 电各向异性大、具有适当的弹性常数、比电阻大和具有适当的前倾角。本发明的目的是提供一种含有该成分的液晶显示装置，该装置的使用温度范围宽、响应时间短、电压保持比大、阈值电压低、对比度大、使用寿命长。
• Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors
  作者：Craig B. Stevens、James M. Hanna、Robin K. Lammi

  DOI：10.1016/j.bmcl.2013.01.076

  日期：2013.3

  3,3',4,4'-Tetrahydroxybiphenyl and three isomeric 3,3 '',4,4 ''-tetrahydroxyterphenyls with varying geometries around the central phenyl ring have been synthesized and evaluated for their in vitro activity against aggregation of Alzheimer's amyloid-beta peptide (A beta). Results from Congo red spectral-shift assays reveal that all four compounds successfully inhibit association of A beta monomers. For the tetrahydroxyterphenyls, efficacy varies with linker geometry: the ortho-arrangement affords the most successful inhibition and the para-geometry the least, perhaps due to differing abilities of these compounds to bind A beta. Of the four small molecules studied, 3,3',4,4'-tetrahydroxybiphenyl is the most effective inhibitor, reducing A beta aggregation by 50% when present in stoichiometric concentrations. (C) 2013 Elsevier Ltd. All rights reserved.