FAVIPIRAVIR杂质14 | 356783-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: FAVIPIRAVIR杂质14
• 英文名称: 3-chloro-6-fluoro-2-pyrazinecarbonitrile
• 英文别名: 3-chloro-6-fluoropyrazine-2-carbonitrile
• CAS: 356783-49-8
• 化学式: C₅HClFN₃
• 分子量: 157.534
• InChiKey: WLSDQWWLYQGWHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-3-氰基吡嗪 在 氮气 、 fluorine 作用下， 以 乙腈 为溶剂， 生成 FAVIPIRAVIR杂质14
  参考文献：
  名称：

  Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof

  摘要：

  具有通式[1]所示的吡嗪衍生物及其盐，其中变量如说明书中所定义，具有优异的抗病毒活性，可作为治疗病毒感染的治疗剂。此外，具有通式[2]所示的氟吡嗪-酰胺衍生物及其盐，其中变量如说明书中所定义，可作为制备通式[1]化合物的中介体，以及作为制备具有抗病毒活性的氟吡嗪-酰胺衍生物的中介体，其中一个典型例子是具有抗病毒活性的6-氟-3-羟基-2-吡嗪酰胺。

  公开号：

  US20030130213A1

文献信息

• Pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof
  申请人：Toyama Chemical Co., Ltd.

  公开号：US06800629B2

  公开（公告）日：2004-10-05

  Pyrazine derivatives represented by general formula [1]: wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine-carboxamide having an antiviral activity.

  一般式[1]所表示的吡嗪衍生物：其中变量如规范中所定义，或其盐具有优异的抗病毒活性，可用作治疗病毒感染的治疗剂。此外，一般式[2]所表示的氟吡嗪羧酰胺衍生物：其中变量如规范中所定义，或其盐，可用作一般式[1]化合物的生产中间体，以及用作生产氟吡嗪羧酰胺衍生物的中间体，其中一个典型例子是具有抗病毒活性的6-氟-3-羟基-2-吡嗪羧酰胺。
• NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1256588A1

  公开（公告）日：2002-11-13

  Pyrazine derivatives represented by general formula [1]: wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine-carboxamide having an antiviral activity.

  通式[1]代表的吡嗪衍生物： 其中的变量如说明书中所定义，或其盐类具有优异的抗病毒活性，可作为治疗病毒感染的治疗剂。 此外，通式[2]代表的氟吡嗪甲酰胺衍生物： 其中的变量如说明书中所定义，或其盐类可用作生产通式[1]化合物的中间体，也可用作生产氟吡嗪-甲酰胺衍生物的中间体，其中一个典型的例子是具有抗病毒活性的6-氟-3-羟基-2-吡嗪-甲酰胺。
• US6800629B2
  申请人：——

  公开号：US6800629B2

  公开（公告）日：2004-10-05
• Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof
  申请人：Toyama Chemical Co., Ltd.

  公开号：US20030130213A1

  公开（公告）日：2003-07-10

  Pyrazine derivatives represented by general formula [1]: 1 wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: 2 wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine-carboxamide having an antiviral activity.

  具有通式[1]所示的吡嗪衍生物及其盐，其中变量如说明书中所定义，具有优异的抗病毒活性，可作为治疗病毒感染的治疗剂。此外，具有通式[2]所示的氟吡嗪-酰胺衍生物及其盐，其中变量如说明书中所定义，可作为制备通式[1]化合物的中介体，以及作为制备具有抗病毒活性的氟吡嗪-酰胺衍生物的中介体，其中一个典型例子是具有抗病毒活性的6-氟-3-羟基-2-吡嗪酰胺。