2-(3-Naphthalen-2-yl-3-oxo-1-phenylpropyl)sulfanylacetic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(3-Naphthalen-2-yl-3-oxo-1-phenylpropyl)sulfanylacetic acid
• 化学式: C₂₁H₁₈O₃S
• 分子量: 350.4
• InChiKey: RLJSGXDZNKHCAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD OF MODULATION OF PROTEIN PHOSPHORYLATION-DEPENDENT CONFORMATIONAL TRANSITIONS WITH LOW MOLECULAR WEIGHT COMPOUNDS
  申请人：Biondi Ricardo M.

  公开号：US20110152166A1

  公开（公告）日：2011-06-23

  The present patent application discloses a method of identifying or validating a compound that modulates the phosphorylation-dependent activity of a target protein or protein complex, where the target protein or protein complex activity is regulated by phosphorylation, as well as the use of identified compounds for the production of a pharmaceutical preparation especially for the treatment of cancer, insulin resistance and diabetes.