2-((4-chlorophenyl)(2-(4-methoxyphenyl)-1H-indol-3-yl)methyl)-1H-indene-1,3(2H)-dione | 1456698-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-((4-chlorophenyl)(2-(4-methoxyphenyl)-1H-indol-3-yl)methyl)-1H-indene-1,3(2H)-dione
• 英文别名: 2-[(4-chlorophenyl)-[2-(4-methoxyphenyl)-1H-indol-3-yl]methyl]indene-1,3-dione
• CAS: 1456698-57-9
• 化学式: C₃₁H₂₂ClNO₃
• 分子量: 491.974
• InChiKey: LCTSKAVSKJNTRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  59.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-甲氧基苯基)-1H-吲哚 、 1,3-茚满二酮 、 4-氯苯甲醛 在 Cu doped ZnS nanoparticles 作用下， 以 水 为溶剂， 反应 2.0h， 以93%的产率得到2-((4-chlorophenyl)(2-(4-methoxyphenyl)-1H-indol-3-yl)methyl)-1H-indene-1,3(2H)-dione
  参考文献：
  名称：

  “On-water” synthesis of 3-substituted indoles via Knoevenagel/Michael addition sequence catalyzed by Cu doped ZnS NPs

  摘要：

  Cu doped ZnS NPs represent a green catalyst for an 'on-water' one-pot rapid synthesis of 3-substituted indole derivatives via Knoevenagel/Michael addition reaction of indane-1,3-dione, aromatic aldehydes, and indole. The catalytic activity of Cu doped ZnS NPs was about sevenfold higher as compared to the ZnS NPs. The Cu doped ZnS NPs catalyst could be recovered and reused for five reaction cycles, giving a total TOF = 201 h(-1). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.013

文献信息

• “On-water” synthesis of 3-substituted indoles via Knoevenagel/Michael addition sequence catalyzed by Cu doped ZnS NPs
  作者：Anshu Dandia、Shyam L. Gupta、Vijay Parewa、Amit Sharma、Kuldeep S. Rathore、Amit Sharma

  DOI：10.1016/j.tetlet.2013.08.013

  日期：2013.10

  Cu doped ZnS NPs represent a green catalyst for an 'on-water' one-pot rapid synthesis of 3-substituted indole derivatives via Knoevenagel/Michael addition reaction of indane-1,3-dione, aromatic aldehydes, and indole. The catalytic activity of Cu doped ZnS NPs was about sevenfold higher as compared to the ZnS NPs. The Cu doped ZnS NPs catalyst could be recovered and reused for five reaction cycles, giving a total TOF = 201 h(-1). (C) 2013 Elsevier Ltd. All rights reserved.