Gamma-L-谷氨酰-Beta-萘酰胺 | 14525-44-1

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: Gamma-L-谷氨酰-Beta-萘酰胺
• 中文别名: N-(Γ-L-谷氨酰)-1-萘胺；Γ-L-谷氨酰-Β-萘酰胺；N-2-萘基-L-谷氨酰胺；Γ-L-谷氨酰-2-萘酰胺；N-(L-谷氨酰基)-β-萘胺；gamma-(beta-萘酰胺)-L-谷氨酸
• 英文名称: (S)-2-Amino-5-(naphthalen-2-ylamino)-5-oxopentanoic acid
• 英文别名: (2S)-2-amino-5-(naphthalen-2-ylamino)-5-oxopentanoic acid
• CAS: 14525-44-1
• 化学式: C₁₅H₁₆N₂O₃
• 分子量: 272.3
• InChiKey: XWCSDVVHAXLZNL-ZDUSSCGKSA-N

物化性质

• 沸点：
  589.1±45.0 °C(Predicted)
• 密度：
  1.329

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R40
• WGK Germany：
  3
• 海关编码：
  2924299090
• 安全说明：
  S22,S36

文献信息

• A process for the identification of bacteria and a kit of reagents for use in this process
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0018825A1

  公开（公告）日：1980-11-12

  A procedure for identification of bacteria comprises subjecting the bacteria to a combination of tests for determination of 26 bacterial enzymes, permitting rapid identification by use of tests generally adapted for determination of constitutive enzymes. The procedure generally permits more rapid identification than previous bacterial identification procedures and is universally applicable to a very wide range of bacteria including most bacteria which are commonly encountered clinically. In a particular embodiment the invention includes a procedure for rapid differentation of the bacterial groups Escherichia, Klebsiella spp., Proteus and Pseudomonas spp., comprising subjecting the bacteria to a combination of tests for determination of bacterial acid phosphatase. beta-galactosidase, glutamate decarboxylase, phenylalanine deaminase, cytochrome oxidase, diacetyl producing enzymes and urease. Additionally the invention includes kits for carrying out the procedures of the invention. typically comprising separate specific substrates for each of the enzymes which it is desired to determine, the kit being preferably in the form of a test card or other suitable apparatus comprising a plurality of wells or compartments which separately contain the enzyme substrates.

  细菌鉴定程序包括对细菌进行测定 26 种细菌酶的组合试验，通过使用一般适用于测定组成酶的试验，可快速鉴定细菌。与以前的细菌鉴定程序相比，该程序一般能更快地鉴定细菌，而且普遍适用于各种细菌，包括临床上常见的大多数细菌。在一个特定的实施方案中，本发明包括一种用于快速鉴别埃希氏菌、克雷伯氏菌属、变形杆菌和假单胞菌属细菌的程序，包括对细菌进行测定细菌酸性磷酸酶、β-半乳糖苷酶、谷氨酸脱羧酶、苯丙氨酸脱氨酶、细胞色素氧化酶、双乙酰产酶和脲酶的组合试验。此外，本发明还包括用于执行本发明程序的试剂盒。试剂盒通常包括用于需要测定的每种酶的单独特异性底物，试剂盒最好采用测试卡或其他适当装置的形式，该装置包括多个分别含有酶底物的孔或隔室。
• Microorganisms detection methods and the separation of agglutinated microorganisms, and a kit for use therein
  申请人：E-Y LABORATORIES, INC.

  公开号：EP0122023A1

  公开（公告）日：1984-10-17

  A test for the differential detection of suspected N. gonorrhoeae (N.g.) and N. meningitidis (N.m.) in provided by contacting a suspected sample with a lectin, preferably wheat germ agglutinin and either soy bean agglutinin or STA potato lectin. An agglutinin reaction is a positive indication of the presence of such microorganisms. Separate portions of the specimen may be contaced with fast substrates specific for (a) N.g., (b) N.m., and (c) B. catarrhalis. Suitable fast substrates are proline naphthylamide, gamma glutamyl naphthylamide, and glycyl prolyl naphthylamide, respectively, each substituted with an electron donating group at the 4-position, 6-position, or both. Another portion of the specimen may be reacted with a substrate for beta-galactosidase enzyme, a positive reaction being an indication that the specimen contains N.lactimica. Autoagglutination, which could otherwise give a false positive in the lectin test, may be prevented by pretreatment of the specimen with DNA'ase and/or an anhydride such as succinic anhydride.

  一种用于鉴别检测疑似淋球菌（N.g.）和脑膜炎双球菌（N.m.）的检测方法是将疑似样本与凝集素（最好是小麦胚芽凝集素和大豆凝集素或 STA 马铃薯凝集素）接触。凝集素反应是此类微生物存在的阳性指标。标本的不同部分可分别与(a) N.g.、(b) N.m.和(c) B. catarrhalis 的特异性快速底物反应。合适的快速底物分别是脯氨酸萘甲酰胺、γ-谷氨酰萘甲酰胺和甘氨酰脯氨酰萘甲酰胺，每种底物都在 4 位、6 位或两者上被电子捐赠基团取代。标本的另一部分可与β-半乳糖苷酶的底物反应，阳性反应表明标本中含有乳酸奈米卡氏菌。用 DNA'ase 和/或酸酐（如琥珀酸酐）对标本进行预处理，可防止自身凝集，否则会在凝集素检测中出现假阳性。
• US4603107A
  申请人：——

  公开号：US4603107A

  公开（公告）日：1986-07-29
• US4603108A
  申请人：——

  公开号：US4603108A

  公开（公告）日：1986-07-29
• [EN] THE IDENTIFICATION OF BACTERIA
  申请人：——

  公开号：WO1980002433A1

  公开（公告）日：1980-11-13

  (EN) A procedure for identification of bacteria comprises subjecting the bacteria to a combination of tests for determination of 26 bacterial enzymes, permitting rapid identification by use of tests generally adapted for determination of constitutive enzymes. The procedure generally permits more rapid identification than previous bacterial identification procedures and is universally applicable to a very wide range of bacteria including most bacteria which are commonly encountered clinically. In a particular embodiment the invention includes a procedure for rapid differentiation of the bacterial groups Escherichia, Klebsiella spp., Proteus and Pseudomonas spp., comprising subjecting the bacteria to a combination of tests for determination of bacterial acid phosphatase, beta-galactosidase, glutamate decarboxylase, phenylalanine deaminase, cytochrome oxidase, diacetyl producing enzymes and urease. Additionally the invention includes kits for carrying out the procedures of the invention, typically comprising separate specific substrates for each of the enzymes which it is desired to determine; the kit being preferably in the form of a test card or other suitable apparatus comprising a plurality of wells or compartments which separately contain the enzyme substrates. (FR) Un procede d'identification de bacteries consiste a soumettre les bacteries a une combinaison de tests de determination de 26 enzymes bacteriens, permettant une identification rapide en utilisant les tests generalement adaptes a la determination d'enzymes constitutifs. Le procede permet de maniere generale une identification plus rapide que les procedes d'identification bacterienne anterieurs et il s'applique de maniere universelle a une tres large variete de bacteries y compris la plupart des bacteries que l'on rencontre habituellement de facon clinique. Dans un mode particulier de realisation, l'invention comprend un procede de differentiation rapide des groupes bacteriens Escherichia, Klebsiella spp., Proteus et Pseudomo nas spp., qui consiste a soumettre les bacteries a une combinaison de tests de determination de phosphatase acide, beta-galactosidase, glutamate decarboxilase, phenylalanine deaminase, cytochrome oxydase, des enzymes produisant du diacetyle et l'urease. De plus, l'invention comprend des ensembles d'outils pour mettre en oeuvre les procedes de l'invention, qui consistent de maniere caracteristique en des substrats specifiques separes pour chacun des enzymes que l'on veut determiner. Ils se presentent de preference sous la forme d'une carte de test ou autre appareil approprie comprenant une pluralite de puits ou compartiments qui contiennent separement les substrats d'enzymes.