2-{[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]methanesulfinyl}-N-(3-nitrophenyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-{[5-Methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]methanesulfinyl}-N-(3-nitrophenyl)acetamide
• 英文别名: 2-[[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]methylsulfinyl]-N-(3-nitrophenyl)acetamide
• 化学式: C20H19N3O5S
• 分子量: 413.4
• InChiKey: ZTPSELXLMIZEOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Oxazole and thiazole compounds as beta-catenin modulators and uses thereof
  申请人：Dasgupta Ramanuj

  公开号：US20090227624A1

  公开（公告）日：2009-09-10

  A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
• US8252823B2
  申请人：——

  公开号：US8252823B2

  公开（公告）日：2012-08-28