N,N-diethyl-2,4,5-trimethyl-benzamide | 54818-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-2,4,5-trimethyl-benzamide
• 英文别名: N,N-diethyl-2,4,5-trimethylbenzamide
• CAS: 54818-96-1
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: NXWFGEAPHGWCLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-phenyl-N'-(1-p-tolyl-ethylidene)hydrazine 、 N,N-diethyl-2,4,5-trimethyl-benzamide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以42%的产率得到3-[2-(4-methoxy-benzyloxy)-phenyl]-6,7-dimethyl-2H-isoquinolin-1-one
  参考文献：
  名称：

  新型的5-氧杂原小ber碱的合成作为原小bio碱的生物等排体

  摘要：

  合成了5-Oxaprotoberberinones和5-oxaprotoberberinium作为原小ber碱的生物等排体。通过亚甲氧基桥将苯酚与3-苯酚异喹啉酮的异喹诺酮环连接，制得5-氧杂小ino碱酮，而5-氧杂小in碱的内酰胺部分的还原和氧化反应可合成季铵化的5-氧杂小ber碱盐。

  DOI：

  10.1016/j.tetlet.2014.01.020

文献信息

• PROCESS FOR PRODUCING ALPHA, ALPHA- DIFLUOROAMINE
  申请人：National University Corporation Hokkaido University

  公开号：EP1813596A1

  公开（公告）日：2007-08-01

  A process for producing an α,α-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an α,α-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.

  一种生产α,α-二氟化胺的工艺，包括在以α,α-二卤胺为底物的卤-氟交换反应中使用一定量的氟化氢和路易斯碱。该工艺可应用于工业，能在短时间内以高产率获得目标化合物，而且操作简便，生产效率极高。
• PROCESS FOR PRODUCING ALPHA, ALPHA-DIFLUOROAMINE
  申请人：Fukuhara Tsuyoshi

  公开号：US20090177012A1

  公开（公告）日：2009-07-09

  A process for producing an α,α-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an α,α-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.
• US7829741B2
  申请人：——

  公开号：US7829741B2

  公开（公告）日：2010-11-09
• Synthesis of novel 5-oxaprotoberberines as bioisosteres of protoberberines
  作者：Yifeng Jin、Daulat Bikram Khadka、Su Hui Yang、Chao Zhao、Won-Jea Cho

  DOI：10.1016/j.tetlet.2014.01.020

  日期：2014.2

  5-Oxaprotoberberinones and 5-oxaprotoberberinium were synthesized as bioisosteres of protoberberines. 5-Oxaprotoberberinones were prepared by linking phenol with the isoquinolone ring of 3-phenolisoquinolones by methyleneoxy bridge, while the quaternary 5-oxaprotoberberinium salt was synthesized by reduction and oxidation of the lactam moiety of 5-oxaprotoberberinone.

  合成了5-Oxaprotoberberinones和5-oxaprotoberberinium作为原小ber碱的生物等排体。通过亚甲氧基桥将苯酚与3-苯酚异喹啉酮的异喹诺酮环连接，制得5-氧杂小ino碱酮，而5-氧杂小in碱的内酰胺部分的还原和氧化反应可合成季铵化的5-氧杂小ber碱盐。