2-Aminocarbonyl-3-methyloxiran | 4417-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 2-Aminocarbonyl-3-methyloxiran
• 英文别名: 3,3-Dimethyl-glycidsaeure-amid；3,3-dimethyl-oxiranecarboxylic acid amide；α,β-epoxy-isovaleric acid amide；α,β-Epoxy-isovaleriansaeure-amid；2,3-Epoxy-3-methylbutyramide；3,3-dimethyloxirane-2-carboxamide
• CAS: 4417-89-4
• 化学式: C₅H₉NO₂
• mdl: MFCD01737124
• 分子量: 115.132
• InChiKey: VHQRLFJQBSEHIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Aminocarbonyl-3-methyloxiran 生成 4-hydroxy-1,5,5-trimethyl-2-phenyl-pyrazolidin-3-one
  参考文献：
  名称：

  Posterior Lumbar Interbody Fusion

  摘要：

  Posterior lumbar interbody fusion has been practiced for more than 50 years. There is little question that interbody techniques offer a significantly higher fusion rate than traditional posterolateral techniques, but the morbidity associated with autograft harvest, the risks of root injury or dural tear during graft placement, and the high pseudarthrosis rate noted when allograft is substituted for autograft have conspired to minimize the widespread use of the procedure.Recently, various types of interbody cages have been developed in an effort to minimize autograft harvest requirements, reestablish disc and foraminal height, and decrease the risks of graft extrusion or collapse. Instrumentation developed for the placement of such cages has improved the surgeon's ability to perform complete discectomy, to properly prepare endplates, to reestablish lordosis, and to minimize the risk to the exiting nerve roots and dural canal.An experienced surgeon may expect fusion rates of 80% to 90% in one or two level lumbar fusions performed for degenerative disease using current techniques. Future improvements using more biocompatible or bioresorbable devices and various bone morphogenetic proteins will extend the life of these techniques well into the next century.

  DOI：

  10.1097/00127927-200106000-00006
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 ammonium hydroxide 作用下， 生成 2-Aminocarbonyl-3-methyloxiran
  参考文献：
  名称：

  Posterior Lumbar Interbody Fusion

  摘要：

  Posterior lumbar interbody fusion has been practiced for more than 50 years. There is little question that interbody techniques offer a significantly higher fusion rate than traditional posterolateral techniques, but the morbidity associated with autograft harvest, the risks of root injury or dural tear during graft placement, and the high pseudarthrosis rate noted when allograft is substituted for autograft have conspired to minimize the widespread use of the procedure.Recently, various types of interbody cages have been developed in an effort to minimize autograft harvest requirements, reestablish disc and foraminal height, and decrease the risks of graft extrusion or collapse. Instrumentation developed for the placement of such cages has improved the surgeon's ability to perform complete discectomy, to properly prepare endplates, to reestablish lordosis, and to minimize the risk to the exiting nerve roots and dural canal.An experienced surgeon may expect fusion rates of 80% to 90% in one or two level lumbar fusions performed for degenerative disease using current techniques. Future improvements using more biocompatible or bioresorbable devices and various bone morphogenetic proteins will extend the life of these techniques well into the next century.

  DOI：

  10.1097/00127927-200106000-00006

文献信息

• Fourneau et al., Journal de Pharmacie et de Chimie, 1934, vol. <8> 19, p. 49,50, 52
  作者：Fourneau et al.

  DOI：——

  日期：——
• DE583243
  申请人：——

  公开号：——

  公开（公告）日：——
• Martynow, Zhurnal Obshchei Khimii, 1953, vol. 23, p. 1654,1657;engl.Ausg.S.1735,1737
  作者：Martynow

  DOI：——

  日期：——
• DE588045
  申请人：——

  公开号：——

  公开（公告）日：——
• Posterior Lumbar Interbody Fusion
  作者：Mark D. Oliver、David W. Cahill、Michael V. Hajjar

  DOI：10.1097/00127927-200106000-00006

  日期：2001.6

  Posterior lumbar interbody fusion has been practiced for more than 50 years. There is little question that interbody techniques offer a significantly higher fusion rate than traditional posterolateral techniques, but the morbidity associated with autograft harvest, the risks of root injury or dural tear during graft placement, and the high pseudarthrosis rate noted when allograft is substituted for autograft have conspired to minimize the widespread use of the procedure.Recently, various types of interbody cages have been developed in an effort to minimize autograft harvest requirements, reestablish disc and foraminal height, and decrease the risks of graft extrusion or collapse. Instrumentation developed for the placement of such cages has improved the surgeon's ability to perform complete discectomy, to properly prepare endplates, to reestablish lordosis, and to minimize the risk to the exiting nerve roots and dural canal.An experienced surgeon may expect fusion rates of 80% to 90% in one or two level lumbar fusions performed for degenerative disease using current techniques. Future improvements using more biocompatible or bioresorbable devices and various bone morphogenetic proteins will extend the life of these techniques well into the next century.