7-Methoxy-1,4,6-trimethyl-9H-carbazole | 919090-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-Methoxy-1,4,6-trimethyl-9H-carbazole
• CAS: 919090-31-6
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: MBGIPCNUKVXBRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲苄基溴 、 2-chloro-5-methoxy-4-methylaniline 在 palladium diacetate 、 sodium t-butanolate 、 tri tert-butylphosphoniumtetrafluoroborate 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以69%的产率得到7-Methoxy-1,4,6-trimethyl-9H-carbazole
  参考文献：
  名称：

  N-H Carbazole Synthesis from 2-Chloroanilines via Consecutive Amination and C−H Activation

  摘要：

  N-H carbazoles can be produced from 2-chloroanilines and aryl bromides via consecutive catalytic amination and C-H activation. In many instances, this can be done in a tandem manner in one pot. The methodologies developed can be used in the synthesis of a range of carbazoles, including the natural products Clausine P and glycozolidine and a precursor in the synthesis of Clausines H, K, O, and 7-methoxy-O-methylmukonal, and can be extended to the synthesis of indoles.

  DOI：

  10.1021/jo061749g

文献信息

• <i>N</i>-H Carbazole Synthesis from 2-Chloroanilines via Consecutive Amination and C−H Activation
  作者：Robin B. Bedford、Michael Betham

  DOI：10.1021/jo061749g

  日期：2006.12.1

  N-H carbazoles can be produced from 2-chloroanilines and aryl bromides via consecutive catalytic amination and C-H activation. In many instances, this can be done in a tandem manner in one pot. The methodologies developed can be used in the synthesis of a range of carbazoles, including the natural products Clausine P and glycozolidine and a precursor in the synthesis of Clausines H, K, O, and 7-methoxy-O-methylmukonal, and can be extended to the synthesis of indoles.