Piv-L-Pro-NHi-Pr | 117368-43-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Piv-L-Pro-NHi-Pr
• 英文别名: Piv-Pro-NH-iPr；(2S)-1-(2,2-dimethylpropanoyl)-N-propan-2-ylpyrrolidine-2-carboxamide
• CAS: 117368-43-1
• 化学式: C₁₃H₂₄N₂O₂
• 分子量: 240.346
• InChiKey: YBGQSAWNZFKSDF-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢-1H,3H-吡咯并[1,2-c]恶唑-1,3-二酮 以 二氯甲烷 为溶剂， 反应 0.46h， 生成 Piv-L-Pro-NHi-Pr
  参考文献：
  名称：

  Hosten, N.; Antenuis, M.J.O, Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 1, p. 48 - 50

  摘要：

  DOI：

文献信息

• Influence of Silaproline on Peptide Conformation and Bioactivity
  作者：Florine Cavelier、Bertrand Vivet、Jean Martinez、André Aubry、Claude Didierjean、André Vicherat、Michel Marraud

  DOI：10.1021/ja017440q

  日期：2002.3.1

  The analogue gamma-(dimethylsila)-proline, denoted silaproline (Sip), was synthesized in both enantiomerically pure forms by diastereoselective alkylation of a chiral glycine equivalent with use of Scholkopf's bis-lactim ether method. The effect of replacing a proline residue in model peptides by this new proline surrogate has been examined in the crystal state by X-ray diffraction and in solution by IR absorption and NMR techniques. Silaproline and proline-containing sequences exhibit very similar conformational properties. Silaproline was also substituted for proline in a neurotensin (8-13) analogue that retained biological activity and exhibited enhanced resistance to biodegradation.
• Hosten, N.; Antenuis, M.J.O, Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 1, p. 48 - 50
  作者：Hosten, N.、Antenuis, M.J.O

  DOI：——

  日期：——