1-ethylphosphonate de diethyle | 146037-31-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-ethylphosphonate de diethyle
• 英文别名: Ethyl 2-(2-diethoxyphosphorylpropanoylamino)acetate
• CAS: 146037-31-2
• 化学式: C₁₁H₂₂NO₆P
• 分子量: 295.273
• InChiKey: ZCWLVDDRXLEMAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,2：3,4-二-O-异亚丙基-α-D-半乳糖-己二醛-1,5-吡喃糖 、 1-ethylphosphonate de diethyle 在 lithium diisopropyl amide 作用下， 生成 [(Z)-2-Methyl-3-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-acryloylamino]-acetic acid ethyl ester
  参考文献：
  名称：

  Synthèse dérivés insaturés d'acides α-aminés précurseurs de pseudoglycopeptides

  摘要：

  The reaction between lithiated anions derived from N-substituted (diethyl-beta-ketophosphono)-alpha-aminoacids and aldehyde compounds gives direct access to unsaturated derivatives of alpha-aminoacids. Application to the glucidic serie leads to an attractive route to pseudoglycopeptide precursors.

  DOI：

  10.1016/s0040-4039(00)73557-x
• 作为产物：
  描述：

  甘氨酸乙酯盐酸盐 、 (2-(diethoxyphosphoryl)propanoyl)tris(dimethylamino)phosphonium 1H-benzo[d][1,2,3]triazol-1-olate 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以97%的产率得到1-ethylphosphonate de diethyle
  参考文献：
  名称：

  Synthese de peptides modifies incorporant un motif phosphore n ou c terminal

  摘要：

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.

  DOI：

  10.1016/s0040-4020(01)92278-1

文献信息

• Synthese de peptides modifies incorporant un motif phosphore n ou c terminal
  作者：Ph. Coutrot、C. Grison、C. Charbonnier-Gérardin

  DOI：10.1016/s0040-4020(01)92278-1

  日期：1992.11

  A general route to phosphopeptids with a 2-oxoalkylphosphonate moiety at the terminal N-aminogroup or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described. The method allows the preparation of various phosphopeptids with an alpha-alkylated carbon atom on the P-C bond from the very available dialkylphosphonoalcanoic acids as starting products.
• Synthèse dérivés insaturés d'acides α-aminés précurseurs de pseudoglycopeptides
  作者：Ph. Coutrot、C. Grison、C. Gérardin-Charbonnier、M. Lecouvey

  DOI：10.1016/s0040-4039(00)73557-x

  日期：1993.4

  The reaction between lithiated anions derived from N-substituted (diethyl-beta-ketophosphono)-alpha-aminoacids and aldehyde compounds gives direct access to unsaturated derivatives of alpha-aminoacids. Application to the glucidic serie leads to an attractive route to pseudoglycopeptide precursors.