di-morpholin-4-yl-phosphinothioic acid hydrazide | 59895-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: di-morpholin-4-yl-phosphinothioic acid hydrazide
• 英文别名: Dimorpholin-4-ylphosphinothioylhydrazine
• CAS: 59895-94-2
• 化学式: C₈H₁₉N₄O₂PS
• 分子量: 266.304
• InChiKey: HMEFVSWBXCKUTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  di-morpholin-4-yl-phosphinothioic acid hydrazide 、 丙酮 以90%的产率得到4-[Morpholin-4-yl-(2-propan-2-ylidenehydrazinyl)phosphinothioyl]morpholine
  参考文献：
  名称：

  Cremlyn, Richard J.; Patel, Kantilal; Wu, Luke, Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 1457 - 1464

  摘要：

  DOI：
• 作为产物：
  描述：

  Dimorpholinophosphorochloridothioate 在 肼 作用下， 以93%的产率得到di-morpholin-4-yl-phosphinothioic acid hydrazide
  参考文献：
  名称：

  Cremlyn, Richard J.; Patel, Kantilal; Wu, Luke, Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 1457 - 1464

  摘要：

  DOI：

文献信息

• Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones
  作者：L. A. Cates、Y. M. Cho、L. K. Smith、L. Williams、T. L. Lemke

  DOI：10.1021/jm00231a010

  日期：1976.9

  Six pyridine-2-carboxaldehyde, one pyridine N-oxide 2-carboxaldehyde, and five diketone thiophosphoric hydrazones, three thiophosphoric hydrazides, and two cupric chelates were synthesized. The chelates and nine of the hydrazones were tested against Ehrlich ascites carcinoma. Seven of these latter agents were administered concurrently with either cupric and/or ferrous salts to mice bearing this tumor. The greatest activity was found with the chelate, cimethyl pyridine-2-carboxyaldehyde phosphorothioic hydrazone-copper (1:1). The hydrazone portion of this chelate also formed a ligand-copper (2:1) complex. Although all of the hydrazones but one were inactive when evaluated alone, the concurrent injection of cupric ion increased survival times by an avoli alkaline phosphatase was found to be inhibited by two thiosemicarbazones in a manner similar to that previously reported by these agents against alkaline phosphatase derived from Sarcoma 180-6-thiopurine resistant ascites cells. None of the 14 hydrazides or hydrazones tested against E. coli enzyme displayed significant inhibition.
• CREMLYN, R.;WU, L., CHEM. AND IND., 1983, N 9, 354
  作者：CREMLYN, R.、WU, L.

  DOI：——

  日期：——
• CREMLYN, R. J.;PATEL, K.;WU, L., J. HETEROCYCL. CHEM., 1984, 21, N 5, 1457-1464
  作者：CREMLYN, R. J.、PATEL, K.、WU, L.

  DOI：——

  日期：——