Acethydrazide, 2--tert-butoxycarbonylamino-N2-benzyloxycarbonyl- | 33350-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Acethydrazide, 2--tert-butoxycarbonylamino-N2-benzyloxycarbonyl-
• 英文别名: benzyl N-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]carbamate
• CAS: 33350-28-6
• 化学式: C₁₅H₂₁N₃O₅
• 分子量: 323.349
• InChiKey: MVSHPVVMRALZCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Acethydrazide, 2--tert-butoxycarbonylamino-N2-benzyloxycarbonyl- 在 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Chelate oxorhenium to assemble new integrin antagonists

  摘要：

  Assembly of independent chemical modules through oxorhenium coordination by a NS2 + S chelation motif was applied to the synthesis of RGD (Arg-Gly-Asp) analogs. Modules were assembled through oxorhenium chelation to give a series of 18 metal complexes in good yields and satisfactory purities. Screening of these oxorhenium coordinates as antagonists of integrins alpha V beta 3, alpha IIb beta 3 and alpha V beta 5 led to the identification of 3 bioactive compounds that exhibit submicromolar affinities for the 3 integrins. Preliminary studies showed that the corresponding oxotechnetium complexes are stable in mice plasma and therefore could be proposed for the molecular imaging of pathologies that overexpress integrins alpha V beta 3 and alpha V beta 5. (C) 2011 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2011.03.008
• 作为产物：
  描述：

  BOC-甘氨酸 、 肼基甲酸苄酯 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 6-氯-1-羟基苯并三氮唑 作用下， 生成 Acethydrazide, 2--tert-butoxycarbonylamino-N2-benzyloxycarbonyl-
  参考文献：
  名称：

  Chelate oxorhenium to assemble new integrin antagonists

  摘要：

  Assembly of independent chemical modules through oxorhenium coordination by a NS2 + S chelation motif was applied to the synthesis of RGD (Arg-Gly-Asp) analogs. Modules were assembled through oxorhenium chelation to give a series of 18 metal complexes in good yields and satisfactory purities. Screening of these oxorhenium coordinates as antagonists of integrins alpha V beta 3, alpha IIb beta 3 and alpha V beta 5 led to the identification of 3 bioactive compounds that exhibit submicromolar affinities for the 3 integrins. Preliminary studies showed that the corresponding oxotechnetium complexes are stable in mice plasma and therefore could be proposed for the molecular imaging of pathologies that overexpress integrins alpha V beta 3 and alpha V beta 5. (C) 2011 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2011.03.008

文献信息

• Chelate oxorhenium to assemble new integrin antagonists
  作者：Julien Le Gal、Marta Gonera、Marie-Anne Lelait、Denis Servent、Christophe Dugave

  DOI：10.1016/j.jinorgbio.2011.03.008

  日期：2011.6

  Assembly of independent chemical modules through oxorhenium coordination by a NS2 + S chelation motif was applied to the synthesis of RGD (Arg-Gly-Asp) analogs. Modules were assembled through oxorhenium chelation to give a series of 18 metal complexes in good yields and satisfactory purities. Screening of these oxorhenium coordinates as antagonists of integrins alpha V beta 3, alpha IIb beta 3 and alpha V beta 5 led to the identification of 3 bioactive compounds that exhibit submicromolar affinities for the 3 integrins. Preliminary studies showed that the corresponding oxotechnetium complexes are stable in mice plasma and therefore could be proposed for the molecular imaging of pathologies that overexpress integrins alpha V beta 3 and alpha V beta 5. (C) 2011 Elsevier Inc. All rights reserved.