(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-2-isobutyl-5-hydroxy-7-phenylheptanoyl amide | 500767-13-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-2-isobutyl-5-hydroxy-7-phenylheptanoyl amide
• 英文别名: tert-butyl N-[(2S,3S)-4-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
• CAS: 500767-13-5
• 化学式: C₂₁H₃₅N₃O₄
• 分子量: 393.527
• InChiKey: MIPYGSILCIWTIB-BZSNNMDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-2-isobutyl-5-hydroxy-7-phenylheptanoyl amide 在 盐酸 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 生成 ((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-((S)-1-carbamoyl-3-methyl-butyl)-carbamic acid benzyl ester
  参考文献：
  名称：

  Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

  摘要：

  A series of protease inhibitors targeted at the malarial enzymes plasmepsin I and II, and encompassing a basic hydroxyethylamine transition state isostere scaffold, was prepared. The substituents in the P1' position were varied and the biological activities expressed in K-i-values ranged from 60 to > 2000 nM. A more than 4-fold selectivity for either of the plasmepsins could be achieved. All of the active compounds exhibited high preference for the plasmepsins over cathepsin D, the most closely related human protease. A few active compounds were shown to inhibit parasite growth in cultured infected human erythrocytes. An ED50 value as low as 1.6 muM was observed for one of the inhibitors despite K-i values of 115 nM (Plm I) and 121 nM (Plm II).

  DOI：

  10.1021/jm020951i
• 作为产物：
  描述：

  亮氨酰胺 、 (1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯 以 异丙醇 为溶剂， 以83%的产率得到(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-2-isobutyl-5-hydroxy-7-phenylheptanoyl amide
  参考文献：
  名称：

  Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

  摘要：

  A series of protease inhibitors targeted at the malarial enzymes plasmepsin I and II, and encompassing a basic hydroxyethylamine transition state isostere scaffold, was prepared. The substituents in the P1' position were varied and the biological activities expressed in K-i-values ranged from 60 to > 2000 nM. A more than 4-fold selectivity for either of the plasmepsins could be achieved. All of the active compounds exhibited high preference for the plasmepsins over cathepsin D, the most closely related human protease. A few active compounds were shown to inhibit parasite growth in cultured infected human erythrocytes. An ED50 value as low as 1.6 muM was observed for one of the inhibitors despite K-i values of 115 nM (Plm I) and 121 nM (Plm II).

  DOI：

  10.1021/jm020951i

文献信息

• Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in <i>Plasmodium </i><i>f</i><i>alciparum</i>-Infected Cultured Human Erythrocytes
  作者：Daniel Nöteberg、Elizabeth Hamelink、Johan Hultén、Mats Wahlgren、Lotta Vrang、Bertil Samuelsson、Anders Hallberg

  DOI：10.1021/jm020951i

  日期：2003.2.1

  A series of protease inhibitors targeted at the malarial enzymes plasmepsin I and II, and encompassing a basic hydroxyethylamine transition state isostere scaffold, was prepared. The substituents in the P1' position were varied and the biological activities expressed in K-i-values ranged from 60 to > 2000 nM. A more than 4-fold selectivity for either of the plasmepsins could be achieved. All of the active compounds exhibited high preference for the plasmepsins over cathepsin D, the most closely related human protease. A few active compounds were shown to inhibit parasite growth in cultured infected human erythrocytes. An ED50 value as low as 1.6 muM was observed for one of the inhibitors despite K-i values of 115 nM (Plm I) and 121 nM (Plm II).