N,N-二丙基丁酰胺 | 14230-95-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N,N-二丙基丁酰胺
• 英文名称: N,N-dipropylbutyramide
• 英文别名: Buttersaeure-dipropylamid；N,N-Dipropyl-butyramid；di-N-propyl-butyramide；N,N-dipropylbutanamide
• CAS: 14230-95-6
• 化学式: C₁₀H₂₁NO
• mdl: MFCD03366198
• 分子量: 171.283
• InChiKey: KAONDSIEAGDWKS-UHFFFAOYSA-N

物化性质

• 熔点：
  230 °C
• 沸点：
  117 °C(Press: 17 Torr)
• 密度：
  0.865±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-二丙基丁酰胺 在 劳森试剂 作用下， 生成 N,N-Dipropylthiobutyramid
  参考文献：
  名称：

  Fritz,H. et al., Bulletin des Societes Chimiques Belges, 1978, vol. 87, p. 525 - 534

  摘要：

  DOI：
• 作为产物：
  描述：

  丁醛肟 、 二正丙胺 在 nickel(II) chloride hexahydrate 作用下， 以 对二甲苯 为溶剂， 反应 18.0h， 生成 N,N-二丙基丁酰胺
  参考文献：
  名称：

  Catalytic Acylation of Amines with Aldehydes or Aldoximes

  摘要：

  The simple nickel salt NiCl2 center dot 6H(2)O catalyzes the coupling of aldoximes with amines to give secondary or tertiary amide products. The aldoxime can be prepared in situ from the corresponding aldehyde. The use of O-18-labeled oximes has allowed insight into the mechanism of this reaction.

  DOI：

  10.1021/ol101978h

文献信息

• Rapid synthesis of aliphatic amides by reaction of carboxylic acids, Grignard reagent and amines: application to the preparation of [11C]amides
  作者：Catherine Aubert、Cécile Huard-Perrio、Marie-Claire Lasne

  DOI：10.1039/a702897k

  日期：——

  Aliphatic amides have been prepared in moderate to good yields (30–70%) by treatment in THF of magnesium halide carboxylates with amines in the presence of 2.5 equivalents of alkylmagnesium halide. The reaction is rapid (<30 min) and has been successfully applied to the synthesis of amides labelled with carbon-11 (β+, t½: 20.4 min). [11C]Aliphatic amides have been obtained in 15–60% radiochemical yields

  在2.5当量烷基卤化镁的存在下，通过用胺在THF中处理卤化镁羧酸盐，可以制备中等至良好收率（30-70％）的脂肪族酰胺。该反应是迅速（<30分钟），并已成功地应用到标记有碳-11酰胺的合成（β +，吨½：20.4分钟）。[ 11 C]已以15-60％的放射化学收率获得了脂族酰胺[衰变校正为轰击结束（EOB），酰胺化反应时间为5分钟]。
• A solvent having switchable hydrophilicity
  作者：Philip G. Jessop、Lam Phan、Andrew Carrier、Shona Robinson、Christoph J. Dürr、Jitendra R. Harjani

  DOI：10.1039/b926885e

  日期：——

  A new kind of switchable solvent, a switchable-hydrophilicity solvent, is hydrophobic and has very low miscibility with water when in air but is hydrophilic and has complete miscibility with water when under an atmosphere of CO2. We report here the first example of such a solvent, N,N,N′-tributylpentanamidine. Solvents such as these could be used for the extraction of low-polarity organic products, such as vegetable oils, followed by the removal of the solvent from the product by carbonated water. Carbonated water is able to extract the solvent from the product because the CO2 converts the solvent to its hydrophilic form. The solvent can then be separated from the carbonated water upon removal of the CO2, because this removal triggers the conversion of the solvent back to its hydrophobic, water-immiscible form. Importantly, distillation is not required for removal of the solvent from the product.

  一种新型可切换溶剂--可切换亲水性溶剂--在空气中是疏水性的，与水的混溶性很低，但在二氧化碳环境下是亲水性的，与水完全混溶。我们在此报告了这种溶剂的第一个例子，即 N,N,N′-三丁基戊脒。这类溶剂可用于萃取植物油等低极性有机产品，然后用碳酸水去除产品中的溶剂。碳酸水能够从产品中萃取出溶剂，因为二氧化碳会将溶剂转化为亲水形式。移除二氧化碳后，溶剂又可以从碳酸水中分离出来，因为移除二氧化碳后，溶剂又会转化为疏水性、不溶于水的形式。重要的是，从产品中去除溶剂不需要蒸馏。
• [EN] SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF<br/>[FR] SOLVANTS COMMUTABLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV KINGSTON

  公开号：WO2011050469A1

  公开（公告）日：2011-05-05

  A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO2, is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.

  描述了一种溶剂，当与水和选择的触发器（例如与CO2接触）接触时，可从疏水液态形式可逆地转变为亲水液态形式。亲水液态形式很容易转变回疏水液态形式和水。疏水液态是一种酰胺或胺。亲水液态形式包括酰胺盐或铵盐。
• [EN] PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF ANEMIA<br/>[FR] COMPOSES DE PYRAZOLOPYRIDINE DESTINES AU TRAITEMENT DE L'ANEMIE
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：WO1993025205A1

  公开（公告）日：1993-12-23

  (EN) The present invention relates to a pharmaceutical composition for the prevention and/or the treatment of anemia in a human being or an animal which comprises, as an active ingredient, a pyrazolopyridine compound of formula (I) wherein R1 is lower alkyl, etc, R2 is a group of formula (II) (wherein R4 is protected amino, etc, and R5 is hydrogen, etc); etc, and R3 is hydrogen, etc, or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier or excipient, etc.(FR) Composition pharmaceutique destinée à la prévention et/ou au traitement de l'anémie chez l'être humain ou chez l'animal. Cette composition comprend comme ingrédient actif un composé de pyrazolopyridine de la formule (I), dans laquelle R1 est un alkyle inférieur, etc.; R2 est un groupe de la formule (II), dans laquelle R4 est un amino protégé, etc. et R5 est l'hydrogène, etc.; etc. et R3 est l'hydrogène, etc.; ou un sel pharmaceutiquement acceptable de ce composé, mélangé à un excipient pharmaceutiquement acceptable, etc.

  本发明涉及一种药物组合物，用于预防和/或治疗人类或动物的贫血，其作为活性成分包含式（I）的吡唑啉并吡啶化合物，其中R1是低碳基等，R2是式（II）的基团（其中R4是保护氨基等，R5是氢等）等，R3是氢等，或其药学上可接受的盐与药学上可接受的载体或赋形剂等混合物。
• Switchable Hydrophilicity Solvents and Methods of Use Thereof
  申请人：Jessop Philip G.

  公开号：US20110257334A1

  公开（公告）日：2011-10-20

  A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO 2 , is described. The hydrophilic liquid form is readily converted back to the hydrophobic liquid form and water. The hydrophobic liquid is an amidine or amine. The hydrophilic liquid form comprises an amidinium salt or an ammonium salt.

  描述了一种溶剂，当与水和选择的触发器（例如，与CO2接触）接触时，可从疏水液态形式可逆地转换为亲水液态形式。亲水液态形式很容易转换回疏水液态形式和水。疏水液体是一种酰胺或胺。亲水液态形式包括酰胺盐或铵盐。