8-(3-oxo-3-phenylprop-1-enyl),3,4-dihydro-2H,6H-3,6-epoxy-naphtho[2,1-b] [1,5]dioxocine | 1342894-92-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 8-(3-oxo-3-phenylprop-1-enyl),3,4-dihydro-2H,6H-3,6-epoxy-naphtho[2,1-b] [1,5]dioxocine
• 英文别名: (E)-1-phenyl-3-(12,16,17-trioxatetracyclo[12.2.1.02,11.05,10]heptadeca-2(11),3,5,7,9-pentaen-4-yl)prop-2-en-1-one
• CAS: 1342894-92-1
• 化学式: C₂₃H₁₈O₄
• 分子量: 358.394
• InChiKey: UVGYBTRACCRZJZ-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  萘酚 在 盐酸 、 三乙胺 、 三氟乙酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 生成 8-(3-oxo-3-phenylprop-1-enyl),3,4-dihydro-2H,6H-3,6-epoxy-naphtho[2,1-b] [1,5]dioxocine
  参考文献：
  名称：

  In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: A new class of antifilarial agents

  摘要：

  A series of 3,6-epoxy [1,5] dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed improved in vitro anti-filarial activity and examples 4d and 4f were also found to be active in the in vivo experiments. These results demonstrate that 3,6-epoxy [1,5] dioxocines exhibits potent antifilarial activity and might be developed into a new class of antifilarial drug. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.009

文献信息

• In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: A new class of antifilarial agents
  作者：Koneni V. Sashidhara、Abdhesh Kumar、K. Bhaskara Rao、Vikas Kushwaha、Kirti Saxena、P.K. Murthy

  DOI：10.1016/j.bmcl.2012.01.009

  日期：2012.2

  A series of 3,6-epoxy [1,5] dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed improved in vitro anti-filarial activity and examples 4d and 4f were also found to be active in the in vivo experiments. These results demonstrate that 3,6-epoxy [1,5] dioxocines exhibits potent antifilarial activity and might be developed into a new class of antifilarial drug. (C) 2012 Elsevier Ltd. All rights reserved.