N,N-二乙基十四烷酰胺 | 57303-20-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N,N-二乙基十四烷酰胺
• 英文名称: N,N-diethyltetradecanamide
• 英文别名: N,N-diethylmyristamide；N-N-Dietilmiristammide
• CAS: 57303-20-5
• 化学式: C₁₈H₃₇NO
• 分子量: 283.498
• InChiKey: DNRJXSFQAZGKPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  肉豆蔻酸 在 氯化亚砜 、 Amberlyst A-21 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N,N-二乙基十四烷酰胺
  参考文献：
  名称：

  Girard; Tranchant; Niore, Synlett, 2000, # 11, p. 1577 - 1580

  摘要：

  DOI：

文献信息

• Studies on Crude Drugs Effective on Visceral Larva Migrans. Part XVI. Nematocidal Activity of Long Alkyl Chain Amides, Amines, and Their Derivatives on Dog Roundworm Larvae.
  作者：Fumiyuki KIUCHI、Satomi NISHZAWA、Hiromi KAWANISHI、Sayuri KINOSHITA、Hisanao OHSIMA、Akiyo UCHITANI、Noriko SEKINO、Miki ISHIDA、Kaoru KONDO、Yoshisuke TSUDA

  DOI：10.1248/cpb.40.3234

  日期：——

  activity of amides and amines having a long alkyl chain against the second-stage larva of dog roundworm, Toxocara canis, was examined. Long chain acyl amides with smaller substituents on the nitrogen showed stronger activity and the activity of cyclic amine amides was stronger than that of acyclic ones. In a series of homologous amides, the activity was dependent on the alkyl chain length: it reached

  检查了具有长烷基链的酰胺和胺对犬round虫第二阶段幼虫的杀线虫活性。在氮上具有较小取代基的长链酰基酰胺显示出更强的活性，环状胺酰胺的活性强于无环酰胺。在一系列同源酰胺中，活性取决于烷基链长：在最佳链长处达到最大值，而在较短和较长的同系物中均降低。通过使用双线性模型分析了同系物的活性与疏水性之间的关系。对于所有中性酰胺，提供最大活性的化合物的疏水性均相似，但分子中具有额外胺基的酰胺具有不同的值。具有长烷基链的叔胺及其盐也具有与相应酰胺相当的杀线虫活性。这些盐以低于其临界胶束浓度的浓度杀死幼虫，表明它们表现为杀线虫作用的单个分子。
• Nickel-catalyzed cross-coupling of unactivated alkyl halides and tosylate carrying a functional group with alkyl and phenyl Grignard reagents
  作者：Surya Prakash Singh、Jun Terao、Nobuaki Kambe

  DOI：10.1016/j.tetlet.2009.07.094

  日期：2009.10

  primary and secondary alkyl Grignard reagents undergo cross-coupling with alkyl bromides, iodide, and tosylate carrying a functional group such as amide, ester, and ketone at 0 °C in THF. The present procedure provides a simple, convenient, and practical method for construction of carbon chains in the presence of various functional groups. PhMgBr also gave the corresponding coupling product in a moderate

  通过使用催化量的镍盐和1,3-丁二烯，伯氏和仲烷基格氏试剂与0处带有官能团（如酰胺，酯和酮）的烷基溴化物，碘化物和甲苯磺酸盐进行交叉偶联。在THF中为°C。本方法提供了在各种官能团存在下构建碳链的简单，方便和实用的方法。PhMgBr还以中等收率得到了相应的偶联产物。
• Regioselective Hydrocarbamoylation of 1-Alkenes
  作者：Yosuke Miyazaki、Yuuya Yamada、Yoshiaki Nakao、Tamejiro Hiyama

  DOI：10.1246/cl.2012.298

  日期：2012.3.5

  Nickel/Lewis acid cooperative catalysis derived from [Ni(cod)2], AlEt3, and N-heterocyclic carbene (NHC) effects highly regioselective hydrocarbamoylation of 1-alkenes. Variously substituted formam...

  源自 [Ni(cod)2]、AlEt3 和 N-杂环卡宾 (NHC) 的镍/路易斯酸协同催化作用可对 1-烯烃进行高度区域选择性的烃甲酰化。各种替代形式...
• One-pot synthesis of amides from carboxylic acids activated using thionyl chloride
  作者：A. Leggio、E. L. Belsito、G. De Luca、M. L. Di Gioia、V. Leotta、E. Romio、C. Siciliano、A. Liguori

  DOI：10.1039/c5ra24527c

  日期：——

  A one-pot synthesis of secondary and tertiary amides from carboxylic acids and amines by using SOCl2 has been developed. Also when sterically hindered amines were used as the starting materials, excellent yields of the corresponding amides were obtained. The amidation of N-protected α-amino acids with secondary amines proceeds effectively with good yields. The process works well also in the presence

  已经开发出通过使用SOCl 2从羧酸和胺一锅合成仲和叔酰胺。同样，当使用位阻胺作为起始原料时，获得了相应酰胺的优异产率。N-保护的α-氨基酸与仲胺的酰胺化有效地以良好的产率进行。该方法在酸敏感基团的存在下也能很好地进行，并且几乎完全保留了手性底物的立体化学完整性。该协议可以扩展到工业大规模生产过程。
• Stabilized antimicrobial compositions and methods of use
  申请人：ISOKLEAN LLC

  公开号：US10542748B2

  公开（公告）日：2020-01-28

  An antimicrobial composition comprising a foil pouch containing water-soluble packets comprising (a) a first water-soluble package comprising C12, C14 and C16 alkyl dimethyl benzyl ammonium chloride, (b) a second water-soluble package comprising trichloromelamine, and (c) a third water-soluble package comprising C12, C14, C16 and C18 alkyl dimethyl benzyl ammonium chloride, C12 and C14 alkyl dimethyl ethylbenzyl ammonium chloride and urea.

  一种抗菌剂组合物，包含一个铝箔袋，袋中装有水溶性包，水溶性包包括：(a) 由 C12、C14 和 C16 烷基二甲基苄基氯化铵组成的第一水溶性包；(b) 由三氯甲烷组成的第二水溶性包；(c) 由 C12、C14、C16 和 C18 烷基二甲基苄基氯化铵、C12 和 C14 烷基二甲基乙基苄基氯化铵和尿素组成的第三水溶性包。