(R)-3-tert-Butoxy-2-isobutoxycarbonylamino-propionic acid | 256666-38-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-3-tert-Butoxy-2-isobutoxycarbonylamino-propionic acid
• 英文别名: (2R)-3-[(2-methylpropan-2-yl)oxy]-2-(2-methylpropoxycarbonylamino)propanoic acid
• CAS: 256666-38-3
• 化学式: C₁₂H₂₃NO₅
• 分子量: 261.318
• InChiKey: GPJWTQFLNROWMT-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (R)-3-tert-Butoxy-2-isobutoxycarbonylamino-propionic acid 在 吡啶 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 [(2R)-3-[[(2S)-1-[[(3S)-2-ethoxy-1-[(Z)-N'-nitrocarbamimidoyl]piperidin-3-yl]amino]-1-oxopropan-2-yl]amino]-2-(2-methylpropoxycarbonylamino)-3-oxopropyl] propan-2-yl carbonate
  参考文献：
  名称：

  Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors

  摘要：

  Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(00)00149-9
• 作为产物：
  描述：

  O-叔丁基-D-丝氨酸 、 氯甲酸异丁酯 在 sodium carbonate 作用下， 以99%的产率得到(R)-3-tert-Butoxy-2-isobutoxycarbonylamino-propionic acid
  参考文献：
  名称：

  Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors

  摘要：

  Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(00)00149-9

文献信息

• Non-covalent inhibitors of urokinase and blood vessel formation
  申请人：DENDREON CORPORATION

  公开号：EP1182207B1

  公开（公告）日：2007-04-18
• Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors
  作者：Susan Y Tamura、Michael I Weinhouse、Christopher A Roberts、Erick A Goldman、Kevin Masukawa、Susanne M Anderson、Cheryl R Cohen、Annette E Bradbury、Vernon T Bernardino、Steven A Dixon、Michael G Ma、Thomas G Nolan、Terence K Brunck

  DOI：10.1016/s0960-894x(00)00149-9

  日期：2000.5

  Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems. (C) 2000 Published by Elsevier Science Ltd.