3-(1H-indol-3-yl)-propionic acid [1-(4-fluoro-phenyl)-meth-(E)-ylidene]-hydrazide | 1157858-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(1H-indol-3-yl)-propionic acid [1-(4-fluoro-phenyl)-meth-(E)-ylidene]-hydrazide
• 英文别名: N-[(E)-(4-fluorophenyl)methylideneamino]-3-(1H-indol-3-yl)propanamide
• CAS: 1157858-21-3
• 化学式: C₁₈H₁₆FN₃O
• 分子量: 309.343
• InChiKey: HZJFIJCSESXZJF-SRZZPIQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  57.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(1H-吲哚-3-基)-丙酸 肼 、 对氟苯甲醛 以 甲苯 为溶剂， 反应 16.0h， 以to afford 0.450 g of white product that的产率得到3-(1H-indol-3-yl)-propionic acid [1-(4-fluoro-phenyl)-meth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS

  摘要：

  本发明涉及N-酰基腙衍生物，其被发现可作为尼古丁乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或障碍，平滑肌收缩相关的疾病或障碍，内分泌疾病或障碍，神经退行性疾病或障碍，炎症、疼痛以及由于滥用化学物质而导致的戒断症状的治疗可能有用。

  公开号：

  US20100280092A1

文献信息

• [EN] N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] DÉRIVÉS DE N-ACYLHYDRAZONE UTILES COMME MODULATEURS DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：NEUROSEARCH AS

  公开号：WO2009065854A1

  公开（公告）日：2009-05-28

  This invention relates to N-acylhydrazone derivatives (I), which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  这项发明涉及N-酰基腙衍生物（I），发现它们可用作尼古丁型乙酰胆碱受体的调节剂。由于其药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或紊乱、内分泌疾病或紊乱、神经退行性疾病或紊乱、炎症、疼痛以及化学物质滥用终止引起的戒断症状等多种疾病或紊乱具有用处。
• N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Nardi Antonio

  公开号：US20100280092A1

  公开（公告）日：2010-11-04

  This invention relates to N-acylhydrazone derivatives, which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及N-酰基腙衍生物，其被发现可作为尼古丁乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或障碍，平滑肌收缩相关的疾病或障碍，内分泌疾病或障碍，神经退行性疾病或障碍，炎症、疼痛以及由于滥用化学物质而导致的戒断症状的治疗可能有用。
• US8101649B2
  申请人：——

  公开号：US8101649B2

  公开（公告）日：2012-01-24
• N-acylhydrazone derivatives useful as modulators of nicotinic acetylcholine receptors
  申请人：Neurosearch A/S

  公开号：US08101649B2

  公开（公告）日：2012-01-24

  This invention relates to N-acylhydrazone derivatives, which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及N-酰基腙衍生物，这些衍生物被发现可用作尼古丁乙酰胆碱受体的调节剂。由于它们的药理特性，本发明中的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症相关的疾病或障碍、疼痛以及由于滥用化学物质的终止而引起的戒断症状具有不同的用处。