Prop-2-yn-1-yl ethylcarbamate | 77248-37-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Prop-2-yn-1-yl ethylcarbamate
• 英文别名: prop-2-ynyl N-ethylcarbamate
• CAS: 77248-37-4
• 化学式: C₆H₉NO₂
• 分子量: 127.14
• InChiKey: ZTANAACTSXSQGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Prop-2-yn-1-yl ethylcarbamate 、 氯化亚砜 生成 prop-2-ynyl N-chlorosulfinyl-N-ethylcarbamate
  参考文献：
  名称：

  FAHMY M. A. H.; FUKUTO T. R., J. AGR. AND FOOD CHEM., 1981, 29, NO 3, 567-572

  摘要：

  DOI：

文献信息

• 10a-Azalide Compound
  申请人：Sugimoto Tomohiro

  公开号：US20090281292A1

  公开（公告）日：2009-11-12

  [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

  【目标】提供一种具有新结构的化合物，对流感嗜血杆菌和红霉素耐药菌（例如耐药肺炎球菌和链球菌）以及传统的红霉素敏感菌具有有效作用。 【解决方案】本发明提供了一种新型10a-氮杂环十六元化合物，其化学式为（I），其药学上可接受的盐或其溶剂化物，或其制备的中间体。该化合物对流感嗜血杆菌、红霉素耐药性肺炎球菌等具有卓越的抗菌活性，因此可以作为治疗传染病的药物。
• METHODS AND COMPOSITIONS RELATED TO NUCLEIC ACID BINDING ASSAYS
  申请人：Nubad, LLC

  公开号：US20140024137A1

  公开（公告）日：2014-01-23

  Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.
• US8097708B2
  申请人：——

  公开号：US8097708B2

  公开（公告）日：2012-01-17
• US8841306B2
  申请人：——

  公开号：US8841306B2

  公开（公告）日：2014-09-23
• US9017943B2
  申请人：——

  公开号：US9017943B2

  公开（公告）日：2015-04-28